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Main Title: Spiral microfluidic devices for cell separation and sorting in bioprocesses
Author(s): Herrmann, Niklas
Neubauer, Peter
Birkholz, Mario
Type: Article
Language Code: en
Abstract: Inertial microfluidic systems have been arousing interest in medical applications due to their simple and cost-efficient use. However, comparably small sample volumes in the microliter and milliliter ranges have so far prevented efficient applications in continuous bioprocesses. Nevertheless, recent studies suggest that these systems are well suited for cell separation in bioprocesses because of their facile adaptability to various reactor sizes and cell types. This review will discuss potential applications of inertial microfluidic cell separation systems in downstream bioprocesses and depict recent advances in inertial microfluidics for bioprocess intensification. This review thereby focusses on spiral microchannels that separate particles at a moderate Reynolds number in a laminar flow (Re < 2300) according to their size by applying lateral hydrodynamic forces. Spiral microchannels have already been shown to be capable of replacing microfilters, extracting dead cells and debris in perfusion processes, and removing contaminant microalgae species. Recent advances in parallelization made it possible to process media on a liter-scale, which might pave the way toward industrial applications.
Issue Date: 5-Nov-2019
Date Available: 13-Nov-2019
DDC Class: 530 Physik
Subject(s): microfluidic system
inertial system
Sponsor/Funder: BMBF, 031B0381, IBÖ-04: SepaDiElo - Mikroelektronik-System zur Zellseparation
Journal Title: Biomicrofluidics
Publisher: American Institute of Physics (AIP)
Publisher Place: Melville, NY
Volume: 13
Issue: 6
Article Number: 061501
Publisher DOI: 10.1063/1.5125264
EISSN: 1932-1058
Notes: This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Biomicrofluidics, 13(6), 61501 and may be found at
Appears in Collections:FG Bioverfahrenstechnik » Publications

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