Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-9270
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Main Title: Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys In Vitro
Author(s): Liu, Zhidan
Schade, Ronald
Luthringer, Bérengère
Hort, Norbert
Rothe, Holger
Müller, Sören
Liefeith, Klaus
Willumeit-Römer, Regine
Feyerabend, Frank
Type: Article
Language Code: en
Abstract: Implantation is a frequent procedure in orthopedic surgery, particularly in the aging population. However, it possesses the risk of infection and biofilm formation at the surgical site. This can cause unnecessary suffering to patients and burden on the healthcare system. Pure Mg, as a promising metal for biodegradable orthopedic implants, exhibits some antibacterial effects due to the alkaline pH produced during degradation. However, this antibacterial effect may not be sufficient in a dynamic environment, for example, the human body. The aim of this study was to increase the antibacterial properties under harsh and dynamic conditions by alloying silver metal with pure Mg as much as possible. Meanwhile, the Mg-Ag alloys should not show obvious cytotoxicity to human primary osteoblasts. Therefore, we studied the influence of the microstructure and the silver content on the degradation behavior, cytocompatibility, and antibacterial properties of Mg-Ag alloys in vitro. The results indicated that a higher silver content can increase the degradation rate of Mg-Ag alloys. However, the degradation rate could be reduced by eliminating the precipitates in the Mg-Ag alloys via T4 treatment. By controlling the microstructure and increasing the silver content, Mg-Ag alloys obtained good antibacterial properties in harsh and dynamic conditions but had almost equivalent cytocompatibility to human primary osteoblasts as pure Mg.
URI: https://depositonce.tu-berlin.de/handle/11303/10308
http://dx.doi.org/10.14279/depositonce-9270
Issue Date: 22-Jun-2017
Date Available: 14-Nov-2019
DDC Class: 610 Medizin und Gesundheit
Subject(s): Mg-Ag alloy
microstructure
degradation
silver content
bioreactor
License: https://creativecommons.org/licenses/by/4.0/
Journal Title: Oxidative Medicine and Cellular Longevity
Publisher: Hindawi Limited
Publisher Place: Austin, Tex.
Volume: 2017
Publisher DOI: 10.1155/2017/8091265
Page Start: 1
Page End: 14
EISSN: 1942-0994
ISSN: 1942-0900
Appears in Collections:FG Metallische Werkstoffe » Publications

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