Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-9901
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Main Title: Kinetics and the Theoretical Aspects of Drug Release from PLA/HAp Thin Films
Author(s): Macha, Innocent J.
Ben-Nissan, Besim
Müller, Wolfgang
Type: Article
Language Code: en
Abstract: The theory of dissolution kinetics of gentamicin from polylactic acid-hydroxyapatite thin film composites is spotlighted with the combination of diffusion and polymer degradation modeling. The use of various mathematical models, characterizing diffusion, dissolution or/and erosion prevalence as well as a mix of dissolution-diffusion rate processes were employed in order to compare theory with experimental data. A number of factors influence the release kinetics of gentamicin from medical drug release systems and devices. It is difficult to have a single mathematical model that takes all these factors into account. It is shown that the degradation of the polymer matrix plays the biggest role in the release kinetics of polymer-ceramics thin film composites. It was also observed that multistage drug release form these devices depends also on the degradation kinetics of the polymer matrix. The effect of pH and device sizes were not studied but could also be of interest in future studies.
URI: https://depositonce.tu-berlin.de/handle/11303/11009
http://dx.doi.org/10.14279/depositonce-9901
Issue Date: 15-Nov-2017
Date Available: 24-Apr-2020
DDC Class: 620 Ingenieurwissenschaften und zugeordnete Tätigkeiten
Subject(s): kinetics
drug dissolution
thin films
coral-derived hydroxyapatite
antibiotic
drug delivery
License: http://rightsstatements.org/vocab/InC/1.0/
Journal Title: Key Engineering Materials
Publisher: Trans Tech Publications
Publisher Place: Uetikon a.S.
Volume: 758
Publisher DOI: 10.4028/www.scientific.net/KEM.758.113
Page Start: 113
Page End: 119
EISSN: 1662-9795
ISSN: 1013-9826
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:FG Kontinuumsmechanik und Materialtheorie » Publications

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