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dc.contributor.authorMacha, Innocent J.-
dc.contributor.authorBen-Nissan, Besim-
dc.contributor.authorMüller, Wolfgang-
dc.date.accessioned2020-04-24T13:04:08Z-
dc.date.available2020-04-24T13:04:08Z-
dc.date.issued2017-11-15-
dc.identifier.issn1013-9826-
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/11009-
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-9901-
dc.descriptionDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.de
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.en
dc.description.abstractThe theory of dissolution kinetics of gentamicin from polylactic acid-hydroxyapatite thin film composites is spotlighted with the combination of diffusion and polymer degradation modeling. The use of various mathematical models, characterizing diffusion, dissolution or/and erosion prevalence as well as a mix of dissolution-diffusion rate processes were employed in order to compare theory with experimental data. A number of factors influence the release kinetics of gentamicin from medical drug release systems and devices. It is difficult to have a single mathematical model that takes all these factors into account. It is shown that the degradation of the polymer matrix plays the biggest role in the release kinetics of polymer-ceramics thin film composites. It was also observed that multistage drug release form these devices depends also on the degradation kinetics of the polymer matrix. The effect of pH and device sizes were not studied but could also be of interest in future studies.en
dc.language.isoenen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.ddc620 Ingenieurwissenschaften und zugeordnete Tätigkeitende
dc.subject.otherkineticsen
dc.subject.otherdrug dissolutionen
dc.subject.otherthin filmsen
dc.subject.othercoral-derived hydroxyapatiteen
dc.subject.otherantibioticen
dc.subject.otherdrug deliveryen
dc.titleKinetics and the Theoretical Aspects of Drug Release from PLA/HAp Thin Filmsen
dc.typeArticleen
tub.accessrights.dnbfreeen
tub.publisher.universityorinstitutionTechnische Universität Berlinen
dc.identifier.eissn1662-9795-
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.4028/www.scientific.net/KEM.758.113en
dcterms.bibliographicCitation.journaltitleKey Engineering Materialsen
dcterms.bibliographicCitation.originalpublisherplaceUetikon a.S.en
dcterms.bibliographicCitation.volume758en
dcterms.bibliographicCitation.pageend119en
dcterms.bibliographicCitation.pagestart113en
dcterms.bibliographicCitation.originalpublishernameTrans Tech Publicationsen
Appears in Collections:FG Kontinuumsmechanik und Materialtheorie » Publications

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