Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-9965
For citation please use:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMaares, Maria-
dc.contributor.authorHaase, Hajo-
dc.date.accessioned2020-05-04T13:16:51Z-
dc.date.available2020-05-04T13:16:51Z-
dc.date.issued2020-03-13-
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/11077-
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-9965-
dc.description.abstractZinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution. In particular, current knowledge on human intestinal zinc absorption and the influence of diet-derived factors on bioaccessibility and bioavailability as well as intrinsic luminal and basolateral factors with an impact on zinc uptake are discussed. Their investigation is increasingly performed using in vitro cellular intestinal models, which are continually being refined and keep gaining importance for studying zinc uptake and transport via the human intestinal epithelium. The vast majority of these models is based on the human intestinal cell line Caco-2 in combination with other relevant components of the intestinal epithelium, such as mucin-secreting goblet cells and in vitro digestion models, and applying improved compositions of apical and basolateral media to mimic the in vivo situation as closely as possible. Particular emphasis is placed on summarizing previous applications as well as key results of these models, comparing their results to data obtained in humans, and discussing their advantages and limitations.en
dc.description.sponsorshipDFG, 316442145, FOR 2558: Interaktionen von essenziellen Spurenelementen in gesunden und erkrankten älteren Menschen (TraceAge)en
dc.description.sponsorshipDFG, 414044773, Open Access Publizieren 2019 - 2020 / Technische Universität Berlinen
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.subject.otherzincen
dc.subject.otherintestinal absorptionen
dc.subject.otherzinc homeostasisen
dc.subject.otherzinc bioavailabilityen
dc.subject.otherzinc uptakeen
dc.subject.otherin vitro intestinal modelen
dc.subject.otherCaco-2en
dc.subject.otherintestinalen
dc.titleA Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Modelsen
dc.typeArticleen
dc.date.updated2020-05-01T22:30:27Z-
tub.accessrights.dnbfreeen
tub.publisher.universityorinstitutionTechnische Universität Berlinen
dc.identifier.eissn2072-6643-
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.3390/nu12030762en
dcterms.bibliographicCitation.journaltitleNutrientsen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume12en
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.issue3en
dcterms.bibliographicCitation.articlenumber762en
Appears in Collections:FG Lebensmittelchemie und Toxikologie » Publications

Files in This Item:
nutrients-12-00762-v3.pdf
Format: Adobe PDF | Size: 2.83 MB
DownloadShow Preview
Thumbnail

Item Export Bar

This item is licensed under a Creative Commons License Creative Commons