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Main Title: Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study
Author(s): Hoeger, Janine
Simon, Tim-Philipp
Beeker, Thorben
Marx, Gernot
Haase, Hajo
Schürholz, Tobias
Type: Article
Language Code: en
Abstract: Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution and prognostic value of serum zinc levels in sepsis patients. We performed a prospective observational single-center study set in a tertiary care university hospital intensive care unit. Serum zinc levels were singularly measured of healthy controls and sequentially of surgical sepsis patients and surgical patients over a 8-day period. Throughout the study period, we report significantly decreased serum zinc levels in surgical and surgical sepsis patients compared to healthy controls. Lower serum zinc levels in surgical sepsis patients were associated with a higher susceptibility to a recurrent sepsis episode. Furthermore, surgical sepsis patients with a higher number of organ dysfunctions and increased in-hospital mortality at day 28 and 90 showed lower serum zinc levels at admission. We report serum zinc levels as a promising biomarker in the diagnosis and evaluation of sepsis patients. However, it is still unclear whether these findings are caused by an over-amplified redistribution of zinc during acute-phase response, or whether the critically ill patients were zinc deficient before sepsis.
Issue Date: 4-May-2017
Date Available: 26-Nov-2020
DDC Class: 610 Medizin und Gesundheit
540 Chemie und zugeordnete Wissenschaften
Subject(s): sepsis
intensive care
Journal Title: PLOS ONE
Publisher: Public Library of Science (PLOS)
Publisher Place: San Francisco, Calif.
Volume: 12
Issue: 5
Article Number: e0176069
Publisher DOI: 10.1371/journal.pone.0176069
EISSN: 1932-6203
Appears in Collections:FG Lebensmittelchemie und Toxikologie » Publications

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