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Main Title: Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow
Author(s): Schoon, Janosch
Hesse, Bernhard
Rakow, Anastasia
Ort, Melanie J.
Lagrange, Adrien
Jacobi, Dorit
Winter, Annika
Huesker, Katrin
Reinke, Simon
Cotte, Marine
Tucoulou, Remi
Marx, Uwe
Perka, Carsten
Duda, Georg N.
Geissler, Sven
Type: Article
Abstract: Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri‐implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri‐implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X‐ray beam allows for spatially resolving the multi‐elemental composition of peri‐implant tissues from patients undergoing revision surgery. In peri‐implant BM, particulate cobalt (Co) is exclusively co‐localized with chromium (Cr), non‐particulate Cr accumulates in the BM matrix. Particles consisting of Co and Cr contain less Co than bulk alloy, which indicates a pronounced dissolution capacity. Particulate titanium (Ti) is abundant in the BM and analyzed Ti nanoparticles predominantly consist of titanium dioxide in the anatase crystal phase. Co and Cr but not Ti integrate into peri‐implant bone trabeculae. The characteristic of Cr to accumulate in the intertrabecular matrix and trabecular bone is reproducible in a human 3D in vitro model. This study illustrates the importance of updating the view on long‐term consequences of biomaterial usage and reveals toxicokinetics within highly sensitive organs.
Subject(s): arthroplasty
bone marrow
metal exposure
synchrotron radiation
Issue Date: 3-Aug-2020
Date Available: 16-Dec-2020
Language Code: en
DDC Class: 600 Technik, Technologie
Sponsor/Funder: BMBF, 01EC1402B, Erkennung und individualisiertes Management der früh beginnenden Osteoporose
Journal Title: Advanced Science
Publisher: Wiley
Volume: 7
Issue: 20
Article Number: 2000412
Publisher DOI: 10.1002/advs.202000412
EISSN: 2198-3844
TU Affiliation(s): Fak. 3 Prozesswissenschaften » Inst. Werkstoffwissenschaften und -technologien » FG Werkstofftechnik
Appears in Collections:Technische Universität Berlin » Publications

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