Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-11081
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dc.contributor.authorSchoon, Janosch-
dc.contributor.authorHesse, Bernhard-
dc.contributor.authorRakow, Anastasia-
dc.contributor.authorOrt, Melanie J.-
dc.contributor.authorLagrange, Adrien-
dc.contributor.authorJacobi, Dorit-
dc.contributor.authorWinter, Annika-
dc.contributor.authorHuesker, Katrin-
dc.contributor.authorReinke, Simon-
dc.contributor.authorCotte, Marine-
dc.contributor.authorTucoulou, Remi-
dc.contributor.authorMarx, Uwe-
dc.contributor.authorPerka, Carsten-
dc.contributor.authorDuda, Georg N.-
dc.contributor.authorGeissler, Sven-
dc.date.accessioned2020-12-16T13:33:23Z-
dc.date.available2020-12-16T13:33:23Z-
dc.date.issued2020-08-03-
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/12206-
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-11081-
dc.description.abstractMetallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri‐implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri‐implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X‐ray beam allows for spatially resolving the multi‐elemental composition of peri‐implant tissues from patients undergoing revision surgery. In peri‐implant BM, particulate cobalt (Co) is exclusively co‐localized with chromium (Cr), non‐particulate Cr accumulates in the BM matrix. Particles consisting of Co and Cr contain less Co than bulk alloy, which indicates a pronounced dissolution capacity. Particulate titanium (Ti) is abundant in the BM and analyzed Ti nanoparticles predominantly consist of titanium dioxide in the anatase crystal phase. Co and Cr but not Ti integrate into peri‐implant bone trabeculae. The characteristic of Cr to accumulate in the intertrabecular matrix and trabecular bone is reproducible in a human 3D in vitro model. This study illustrates the importance of updating the view on long‐term consequences of biomaterial usage and reveals toxicokinetics within highly sensitive organs.en
dc.description.sponsorshipBMBF, 01EC1402B, Erkennung und individualisiertes Management der früh beginnenden Osteoporoseen
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc600 Technik, Technologiede
dc.subject.otherarthroplastyen
dc.subject.otherbone marrowen
dc.subject.othermetal exposureen
dc.subject.othernanoparticlesen
dc.subject.othersynchrotron radiationen
dc.titleMetal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrowen
dc.typeArticleen
dc.date.updated2020-12-07T10:45:35Z-
tub.accessrights.dnbfreeen
tub.publisher.universityorinstitutionTechnische Universität Berlinen
dc.identifier.eissn2198-3844-
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1002/advs.202000412en
dcterms.bibliographicCitation.journaltitleAdvanced Scienceen
dcterms.bibliographicCitation.originalpublisherplaceNew York, NYen
dcterms.bibliographicCitation.volume7en
dcterms.bibliographicCitation.originalpublishernameWileyen
dcterms.bibliographicCitation.issue20en
dcterms.bibliographicCitation.articlenumber2000412en
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