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Main Title: Secondary metabolite arsenal of an opportunistic pathogenic fungus
Author(s): Bignell, Elaine
Cairns, Timothy C.
Throckmorton, Kurt
Nierman, William C.
Keller, Nancy P.
Type: Article
Language Code: en
Abstract: Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGCs) producing bioactive small molecules (often referred to as secondary metabolites or natural products) that provide growth advantages to the fungus dependent on environment. Here we summarize the current knowledge of these BGCs—18 of which can be named to product—their expression profiles in vivo, and which BGCs may enhance virulence of this opportunistic human pathogen. Furthermore, we find extensive evidence for the presence of many of these BGCs, or similar BGCs, in distantly related genera including the emerging pathogen Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats, and suggest such BGCs may be predictive of pathogenic potential in other fungi.
Issue Date: 5-Dec-2016
Date Available: 18-Jan-2021
DDC Class: 570 Biowissenschaften; Biologie
Subject(s): Aspergillus fumigatus
secondary metabolism
gene cluster
fungal infection
Journal Title: Philosophical Transactions of the Royal Society of London, Series B : Biological Sciences
Publisher: Royal Society of London
Publisher Place: London
Volume: 371
Issue: 1709
Article Number: 20160023
Publisher DOI: 10.1098/rstb.2016.0023
EISSN: 1471-2970
ISSN: 0962-8436
Appears in Collections:FG Angewandte und Molekulare Mikrobiologie » Publications

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