Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-11908
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Main Title: Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition
Author(s): Tran, Hoai T. T.
Stetter, Rebecca
Herz, Corinna
Spöttel, Jenny
Krell, Mareike
Hanschen, Franziska S.
Schreiner, Monika
Rohn, Sascha
Behrens, Maik
Lamy, Evelyn
Type: Article
URI: https://depositonce.tu-berlin.de/handle/11303/13115
http://dx.doi.org/10.14279/depositonce-11908
License: https://creativecommons.org/licenses/by/4.0/
Abstract: Understanding individual responses to nutrition and medicine is of growing interest and importance. There is evidence that differences in bitter taste receptor (TAS2R) genes which give rise to two frequent haplotypes, TAS2R38-PAV (functional) and TAS2R38-AVI (non-functional), may impact inter-individual differences in health status. We here analyzed the relevance of the TAS2R38 receptor in the regulation of the human immune response using the TAS2R38 agonist allyl isothiocyanate (AITC) from Brassica plants. A differential response in calcium mobilization upon AITC treatment in leucocytes from healthy humans confirmed a relevance of TAS2R38 functionality, independent from cation channel TRPV1 or TRPA1 activation. We further identified a TAS2R38-dependence of MAPK and AKT signaling activity, bactericidal (toxicity against E. coli) and anti-inflammatory activity (TNF-alpha inhibition upon cell stimulation). These in vitro results were derived at relevant human plasma levels in the low micro molar range as shown here in a human intervention trial with AITC-containing food.
Subject(s): Brassica plants
Brassicaceae
isothiocyanates
human bitter taste receptor
TAS2R38
personalized (precision) nutrition
precision medicine
precision health
Issue Date: 20-Apr-2021
Date Available: 18-May-2021
Language Code: en
DDC Class: 610 Medizin und Gesundheit
Journal Title: Frontiers in Immunology
Publisher: Frontiers
Volume: 12
Article Number: 669005
Publisher DOI: 10.3389/fimmu.2021.669005
EISSN: 1664-3224
TU Affiliation(s): Fak. 3 Prozesswissenschaften » Inst. Lebensmitteltechnologie und Lebensmittelchemie » FG Lebensmittelchemie und Analytik
Appears in Collections:Technische Universität Berlin » Publications

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