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Main Title: Anticipating alien cells with alternative genetic codes: away from the alanine world!
Author(s): Kubyshkin, Vladimir
Budisa, Nediljko
Type: Article
Language Code: en
Abstract: Can we make life with a different genetic amino acid repertoire? Can we expect organisms which would keep newly given genetic code associations permanently? To address these questions, we would like to analyze the existent genetic code amino acid repertoire as formed from derivatives of alanine. Derivation from alanine leads to the α-helix based biological world, the Alanine World, whereas variations in the side-chains enable tertiary folding and subsequent chemical versatility of the proteome. Proline, glycine and pyrrolysine are the rudiments in the current genetic code, indicating that the original set could be different. Furthermore, from the perspective of peptide chemistry, it shall be possible to recruit these alternative scaffolds for the construction of synthetic or alternative life. This would allow for a completely new biological world, potentially as functional and versatile as the existing one. Pursuing these options offers a strategy for a complete re-design or even de-novo creation of living organisms based on entirely different chemical make-up, with completely new set of solutions for both near and distant future biotechnologies.
Issue Date: 3-Jul-2019
Date Available: 10-Jun-2021
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Subject(s): alien cells
genetic code
Sponsor/Funder: DFG, 390540038, EXC 2008: Unifying Systems in Catalysis "UniSysCat"
Journal Title: Current Opinion in Biotechnology
Publisher: Elsevier
Publisher Place: Amsterdam
Volume: 60
Publisher DOI: 10.1016/j.copbio.2019.05.006
Page Start: 242
Page End: 249
EISSN: 1879-0429
ISSN: 0958-1669
Appears in Collections:FG Biokatalyse » Publications

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