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Main Title: SARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendations
Author(s): Kriegel, Martin
Hartmann, Anne
Buchholz, Udo
Seifried, Janna
Baumgarte, Sigrid
Gastmeier, Petra
Type: Article
Abstract: There is uncertainty about the viral loads of infectious individuals required to transmit COVID-19 via aerosol. In addition, there is a lack of both quantification of the influencing parameters on airborne transmission and simple-to-use models for assessing the risk of infection in practice, which furthermore quantify the influence of non-medical preventive measures. In this study, a dose–response model was adopted to analyze 25 documented outbreaks at infection rates of 4–100%. We show that infection was only possible if the viral load was higher than 108 viral copies/mL. Based on mathematical simplifications of our approach to predict the probable situational attack rate (PARs) of a group of persons in a room, and valid assumptions, we provide simplified equations to calculate, among others, the maximum possible number of persons and the person-related virus-free air supply flow necessary to keep the number of newly infected persons to less than one. A comparison of different preventive measures revealed that testing contributes the most to the joint protective effect, besides wearing masks and increasing ventilation. In addition, we conclude that absolute volume flow rate or person-related volume flow rate are more intuitive parameters for evaluating ventilation for infection prevention than air exchange rate.
Subject(s): airborne transmission
infection prevention
risk assessment model
simplified approaches
Issue Date: 25-Dec-2021
Date Available: 5-Jan-2022
Language Code: en
DDC Class: 610 Medizin und Gesundheit
Journal Title: International Journal of Environmental Research and Public Health
Publisher: MDPI
Volume: 19
Issue: 1
Article Number: 220
Publisher DOI: 10.3390/ijerph19010220
EISSN: 1660-4601
ISSN: 1661-7827
TU Affiliation(s): Fak. 3 Prozesswissenschaften » Inst. Energietechnik » FG Gebäudeenergiesysteme
Appears in Collections:Technische Universität Berlin » Publications

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