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Main Title: Microwave-Assisted Synthesis of 5′-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435
Author(s): Chea, Sany
Nguyen, Khac Toan
Rosencrantz, Ruben R.
Type: Article
Abstract: Nucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5′ position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5′-O-methacryloylcytidine with the assistance of microwave irradiation. Variable reaction parameters, such as enzyme concentration, molar ratio of the substrate, reaction temperature and reaction time, were investigated to find the optimum reaction condition in terms of obtaining the highest yield.
Subject(s): microwave irradiation
Novozym 435
smart materials
Issue Date: 26-Jun-2022
Date Available: 11-Jul-2022
Language Code: en
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Journal Title: Molecules
Publisher: MDPI
Volume: 27
Issue: 13
Article Number: 4112
Publisher DOI: 10.3390/molecules27134112
EISSN: 1420-3049
TU Affiliation(s): Fak. 2 Mathematik und Naturwissenschaften » Inst. Chemie
Appears in Collections:Technische Universität Berlin » Publications

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