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Main Title: Arabinoxylan-Based Microcapsules Being Loaded with Bee Products as Bioactive Food Components Are Able to Modulate the Cell Migration and Inflammatory Response—In Vitro Study
Author(s): Kowalska, Gabriela
Rosicka-Kaczmarek, Justyna
Miśkiewicz, Karolina
Zakłos-Szyda, Małgorzata
Rohn, Sascha
Kanzler, Clemens
Wiktorska, Magdalena
Niewiarowska, Jolanta
Type: Article
Abstract: The aim of the research was to use bioactive heteropolysaccharides isolated from rye bran to obtain innovative systems for the controlled release of bioactive compounds. The core of the obtained encapsulates was honey and royal jelly. It was shown for the first time that preparations effectively ameliorated inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, decreasing the secretion of interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and nitric oxide (NO). The in vitro digestion process revealed that bee products’ encapsulates were stronger oxidative stress reducers and had sustained ability to reduction in inflammation state mediators. The lack of inhibitory effect on migration rate of human microvascular endothelial cells (HMEC-1) endothelial cells and mouse embryonic fibroblasts (NIH-3T3), both cell models involved in wound healing process, additionally identified these preparations as agents potentially used in the management of inflammatory response. In the process of a simulated digestion in vitro, the innovative microcapsules showed 85% higher biostability and two to ten times better bioavailability, compared to natural bee products.
Subject(s): rye bran
bioactive heteropolysaccharides
arabinoxylans-based microcapsules
bee products
inflammatory response
Issue Date: 17-Jun-2022
Date Available: 11-Jul-2022
Language Code: en
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Journal Title: Nutrients
Publisher: MDPI
Volume: 14
Issue: 12
Article Number: 2529
Publisher DOI: 10.3390/nu14122529
EISSN: 2072-6643
TU Affiliation(s): Fak. 3 Prozesswissenschaften » Inst. Lebensmitteltechnologie und Lebensmittelchemie » FG Lebensmittelchemie und Analytik
Appears in Collections:Technische Universität Berlin » Publications

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