Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-16074
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Main Title: Rheological characteristics of filamentous cultivation broths and suitable model fluids
Author(s): Bliatsiou, Chrysoula
Schrinner, Kathrin
Waldherr, Chrysoula
Tesche, Sebastian
Böhm, Lutz
Kraume, Matthias
Krull, Rainer
Type: Article
URI: https://depositonce.tu-berlin.de/handle/11303/17293
http://dx.doi.org/10.14279/depositonce-16074
License: https://creativecommons.org/licenses/by/4.0/
Abstract: The rheological characteristics of cultivations with filamentous microorganisms define many other crucial process parameters in the system, such as the cell morphology and the productivity. The present study aims to determine the rheological changes of broths during batch cultivations of three filamentous microorganisms: the fungus Aspergillus niger, and the two actinomycetes Lentzea aerocolonigenes and Actinomadura namibiensis. Focus is given on establishing measurement methodologies to characterize these heterogeneous filamentous systems. For the rheological characterisation the Ostwald-de Waele power law approach is used. All examined biological filamentous broths exhibit a non-Newtonian shear thinning behavior. The effect of biomass concentration and cell morphology on the rheology of the broth is further enlightened. Finally, the rheology of the cultivation broths is compared with that of various model fluids to test the suitability of the last ones to mimic rheologically the biological broths in further technical applications.
Subject(s): rheology
filamentous cultivation broth
cell morphology
model fluid system
non-newtonian behavior
Issue Date: 3-Aug-2020
Date Available: 3-Aug-2022
Language Code: en
DDC Class: 660 Chemische Verfahrenstechnik
Sponsor/Funder: DFG, 273937032, SPP 1934: Dispersitäts-, Struktur- und Phasenänderungen von Proteinen und biologischen Agglomeraten in biotechnologischen Prozessen
Journal Title: Biochemical Engineering Journal
Publisher: Elsevier
Volume: 163
Article Number: 107746
Publisher DOI: 10.1016/j.bej.2020.107746
EISSN: 1873-295X
ISSN: 1369-703X
TU Affiliation(s): Fak. 3 Prozesswissenschaften » Inst. Prozess- und Verfahrenstechnik » FG Verfahrenstechnik
Appears in Collections:Technische Universität Berlin » Publications

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