Institut für Biotechnologie
Community home page

236 Submissions in this community.

Recent Submissions
Role of NOD2 and S100A8/S100A9 in the pathogenesis of Coxsackievirus B3-induced myocarditis

Müller, Irene (2017)

Cardiac inflammation plays a crucial role in Coxsackievirus B3 (CVB3)-induced myocarditis and is a consequence of viral-related cardiomyocyte injury, which activates the innate immune system. The n...

Autoantikörper-induzierte Effekte des Angiotensin II-Rezeptors Typ 1 und des Endothelinrezeptors Typ A auf humane periphere mononukleäre Zellen und ihre Relevanz bei der Pathogenese der systemischen Sklerose

Günther, Jeannine (2017)

Functional autoantibodies (aab) against the angiotensin II receptor type 1 (AT1R) and the endothelin 1 receptor type A (ETAR) have been identified in patients suffering from systemic sclerosis (SSc...

Partielle Charakterisierung der neuartigen humanen Polyomaviren HPyV9 und HPyV12

Korup-Schulz, Sarah-Verena (2017)

Im letzten Jahrzehnt wurden elf neue humane Polyomaviren (PyV) und zahlreiche tierische PyV identifiziert. Die Charakteristika dieser PyV wie Gewebetropismus, zelluläre Eintritts- und Infektionsmec...

Synthetic biomaterial microenvironments to modulate paracrine effects of mesenchymal stromal cells for skeletal muscle regeneration

Qazi, Taimoor Hasan (2017)

While skeletal muscles can recover from minor injuries, severe trauma can often induce irreversible structural damage such as extensive scar tissue formation and damaged muscle fibers. This leads t...

Tissue engineered cartilage: how hard can it be?

Kadler, Shirin (2017)

Für die Weiterentwicklung regenerativer Therapien sind humane in vitro Modelle aus Primärzellen entscheidend. Die Isolation und Expansion primärer Zellen zieht den Verlust der Gewebsspezifität nach...

Distribution of Dehalococcoidia in marine sediments and strategies for their enrichment

Algora, Camelia (2016)

The marine subsurface is one of the largest microbial habitats on Earth. Microbial community studies based on the 16S rRNA gene have revealed that bacteria of the class Dehalococcoidia, phylum Chlo...

Tumorzell-Stroma-Interaktionen beim Multiplen Myelom

Berenstein, Rimma (2016)

Multiple myeloma (MM) is a B-cell malignancy characterized by accumu- lation of malignant plasma cells (PC) within the bone marrow. Bone marrow mesenchymal stromal cells (BMMSCs) represent a cruci...

Investigation of experimental cell lines and non-invasive online sensor technologies in a 3D bioreactor system for extracorporeal liver support therapy

Richter, Marco (2016)

Liver transplantation is currently the only successful treatment to cure acute or acute-on-chronic liver failure. However, the number of patients waiting for a donor organ is constantly rising due ...

Colorectal cancer patient-derived xenograft (PDX) models as platform for drug screening, molecular and response analysis

Rivera, Maria (2016)

Appropriate preclinical in vivo models are of increasing importance and represent an essential tool in recent cancer research. Regarding the current developments in oncology, and particularly in pe...

The role of mast cells in the immune response against bacterial infections

Zimmermann, Carolin (2016)

Skin wound infections are a significant and increasing health problem, and antibiotic resistance is increasing. Mast cells have been shown to contribute to host defence responses in bacterial inf...

Characterization and identification of microbial contaminations and biofilm formation in metal-working-fluids

Langbein, Jennifer Edith (2016)

Microbial contamination in metal working fluids is a long known issue in fluid management with various effects. The microorganisms present pose a potential health hazards as pathogens are found fre...

Engineering of Aspergillus niger for the production of secondary metabolites

Richter, Lennart; Wanka, Franziska; Boecker, Simon; Storm, Dirk; Kurt, Tutku; Vural, Özlem; Süßmuth, Roderich; Meyer, Vera (2014)

Background: Filamentous fungi can each produce dozens of secondary metabolites which are attractive as therapeutics, drugs, antimicrobials, flavour compounds and other high-value chemicals. Further...

Tet-on, or tet-off, that is the question: advanced conditional gene expression in Aspergillus

Wanka, Franziska; Cairns, Timothy; Boecker, Simon; Berens, Christian; Happel, Anna; Zheng, Xiaomei; Sun, Jibin; Krappmann, Sven; Meyer, Vera (2016)

In Aspergillus, controlled gene expression is often achieved using the reverse tetracycline-controlled transactivator (rtTA) dependent Tet-on system, whereby transcription is activated in a titrata...

Gen- und verfahrenstechnische Ansätze zur Optimierung von Aspergillus niger als Expressionsplattform

Wanka, Franziska (2016)

Aspergillus niger has the ability to synthesise large amounts of acids and proteins, and to secrete these into the environment. This particular property is used in biotechnology to produce platform...

Modes of anaerobic respiration catalysed by members of the class Dehalococcoidia

Cooper, Myriel (2016)

The bacterial class Dehalococcoidia, phylum Chloroflexi, encompasses several cultivated strains and many so far uncultivated bacteria, known from molecular detection of their 16S rRNA gene sequence...

Fluorescent optical fiber sensors for cell viability monitoring

Sergachev, Ilia; Rusanov, Alexander; Trushkin, Evgeny; Sakharov, Dmitry; Marx, Uwe; Tonevitsky, Alexander (2013)

A new simple method for non-invasive cell culture viability monitoring based on vital fluorescent stains is introduced, and its efficiency for long-term experiments on cells is demonstrated. In con...

Quality assurance in immunoassay performance – carbamazepine immunoassay format evaluation and application on surface and waste water

Grandke, Julia; Oberleitner, Lidia; Resch-Genger, Ute; Garbe, Leif-Alexander; Schneider, Rudolf J. (2013)

Carbamazepine (CBZ) is one of the most frequently detected pharmaceuticals in water samples. For the determination of this anthropogenic marker, various immunoassay formats were tested and evaluate...

Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput

Materne, Eva-Maria; Tonevitsky, Alexander G.; Marx, Uwe (2013)

Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxic...

Integrating biological vasculature into a multi-organ-chip microsystem

Schimek, Katharina; Busek, Mathias; Brincker, Sven; Groth, Benjamin; Hoffmann, Silke; Lauster, Roland; Lindner, Gerd; Lorenz, Alexandra; Menzel, Ulrike; Sonntag, Frank; Walles, Heike; Marx, Uwe; Horland, Reyk (2013)

A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale. A peristaltic on-chip micropump generates ...

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, Ilka; Materne, Eva-Maria; Brincker, Sven; Süßbier, Ute; Frädrich, Caroline; Busek, Mathias; Sonntag, Frank; Sakharov, Dmitry A.; Trushkin, Evgeny V.; Tonevitsky, Alexander G.; Lauster, Roland; Marx, Uwe (2013)

Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we ...