Algora, Camelia (2016)
The marine subsurface is one of the largest microbial habitats on Earth. Microbial community studies based on the 16S rRNA gene have revealed that bacteria of the class Dehalococcoidia, phylum Chlo...Tumorzell-Stroma-Interaktionen beim Multiplen Myelom
Berenstein, Rimma (2016)
Multiple myeloma (MM) is a B-cell malignancy characterized by accumu- lation of malignant plasma cells (PC) within the bone marrow. Bone marrow mesenchymal stromal cells (BMMSCs) represent a cruci...Investigation of experimental cell lines and non-invasive online sensor technologies in a 3D bioreactor system for extracorporeal liver support therapy
Richter, Marco (2016)
Liver transplantation is currently the only successful treatment to cure acute or acute-on-chronic liver failure. However, the number of patients waiting for a donor organ is constantly rising due ...Colorectal cancer patient-derived xenograft (PDX) models as platform for drug screening, molecular and response analysis
Rivera, Maria (2016)
Appropriate preclinical in vivo models are of increasing importance and represent an essential tool in recent cancer research. Regarding the current developments in oncology, and particularly in pe...The role of mast cells in the immune response against bacterial infections
Zimmermann, Carolin (2016)
Skin wound infections are a significant and increasing health problem, and antibiotic resistance is increasing. Mast cells have been shown to contribute to host defence responses in bacterial inf...Characterization and identification of microbial contaminations and biofilm formation in metal-working-fluids
Langbein, Jennifer Edith (2016)
Microbial contamination in metal working fluids is a long known issue in fluid management with various effects. The microorganisms present pose a potential health hazards as pathogens are found fre...Engineering of Aspergillus niger for the production of secondary metabolites
Richter, Lennart; Wanka, Franziska; Boecker, Simon; Storm, Dirk; Kurt, Tutku; Vural, Özlem; Süßmuth, Roderich; Meyer, Vera (2014)
Background: Filamentous fungi can each produce dozens of secondary metabolites which are attractive as therapeutics, drugs, antimicrobials, flavour compounds and other high-value chemicals. Further...Tet-on, or tet-off, that is the question: advanced conditional gene expression in Aspergillus
Wanka, Franziska; Cairns, Timothy; Boecker, Simon; Berens, Christian; Happel, Anna; Zheng, Xiaomei; Sun, Jibin; Krappmann, Sven; Meyer, Vera (2016)
In Aspergillus, controlled gene expression is often achieved using the reverse tetracycline-controlled transactivator (rtTA) dependent Tet-on system, whereby transcription is activated in a titrata...Gen- und verfahrenstechnische Ansätze zur Optimierung von Aspergillus niger als Expressionsplattform
Wanka, Franziska (2016)
Aspergillus niger has the ability to synthesise large amounts of acids and proteins, and to secrete these into the environment. This particular property is used in biotechnology to produce platform...Modes of anaerobic respiration catalysed by members of the class Dehalococcoidia
Cooper, Myriel (2016)
The bacterial class Dehalococcoidia, phylum Chloroflexi, encompasses several cultivated strains and many so far uncultivated bacteria, known from molecular detection of their 16S rRNA gene sequence...Fluorescent optical fiber sensors for cell viability monitoring
Sergachev, Ilia; Rusanov, Alexander; Trushkin, Evgeny; Sakharov, Dmitry; Marx, Uwe; Tonevitsky, Alexander (2013)
A new simple method for non-invasive cell culture viability monitoring based on vital fluorescent stains is introduced, and its efficiency for long-term experiments on cells is demonstrated. In con...Quality assurance in immunoassay performance – carbamazepine immunoassay format evaluation and application on surface and waste water
Grandke, Julia; Oberleitner, Lidia; Resch-Genger, Ute; Garbe, Leif-Alexander; Schneider, Rudolf J. (2013)
Carbamazepine (CBZ) is one of the most frequently detected pharmaceuticals in water samples. For the determination of this anthropogenic marker, various immunoassay formats were tested and evaluate...Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput
Materne, Eva-Maria; Tonevitsky, Alexander G.; Marx, Uwe (2013)
Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxic...Integrating biological vasculature into a multi-organ-chip microsystem
Schimek, Katharina; Busek, Mathias; Brincker, Sven; Groth, Benjamin; Hoffmann, Silke; Lauster, Roland; Lindner, Gerd; Lorenz, Alexandra; Menzel, Ulrike; Sonntag, Frank; Walles, Heike; Marx, Uwe; Horland, Reyk (2013)
A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale. A peristaltic on-chip micropump generates ...A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
Wagner, Ilka; Materne, Eva-Maria; Brincker, Sven; Süßbier, Ute; Frädrich, Caroline; Busek, Mathias; Sonntag, Frank; Sakharov, Dmitry A.; Trushkin, Evgeny V.; Tonevitsky, Alexander G.; Lauster, Roland; Marx, Uwe (2013)
Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we ...Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
Ataç, Beren; Wagner, Ilka; Horland, Reyk; Lauster, Roland; Marx, Uwe; Tonevitsky, Alexander G.; Azar, Reza P.; Lindner, Gerd (2013)
Substantial progress has been achieved over the last few decades in the development of skin equivalents to model the skin as an organ. However, their static culture still limits the emulation of es...Methodenvalidierung zur Bestimmung der Weichmacher DEHT und DINCH durch die Synthese deuterierter Standards
Canitz, Carsten Jörg (2016)
Die Gesundheitsrelevanz von Phthalatweichmachern und die damit einhergehenden rechtlichen Einschränkungen des Gebrauches haben den Bedarf einer validen Rückstandsanalytik sowohl für ebendiese Weich...Analysis of different modes of TAL effector-mediated transcriptional regulation
Werner, Jeannette (2016)
The continuous development of new technologies like ZFP, TALEs and the CRISPR/Cas system to target chromosomal DNA sequences opens more efficient possibilities to edit genomic loci or to modulate t...Response of Escherichia coli processes for the production of heterologous inclusion bodies by oscillating cultivation conditions in a scale-down bioreactor
Lu, Ping (2016)
In the pharmaceutical, chemical and food industries, microorganisms are widely cultivated under controlled conditions to produce recombinant proteins and organic molecules. However, inhomogeneities...Production of polyhydroxyalkanoate from high cell density fermentations using palm oil and waste animal fats as carbon feedstocks and their recovery with non-halogenated solvents
Riedel, Sebastian Lothar Stefan (2016)
Polyhydroxyalkanoates (PHAs) are polyesters that have similar properties to conventional plastic materials. Many microorganisms synthesize versatile PHAs as carbon and energy storage under nutrient...
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