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Impact of oscillations in substrate and oxygen availability on Corynebacterium glutamicum cultivations

Lemoine, Anja Irene (2017)

Corynebacterium glutamicum is a microorganism which is highly relevant for industrial large scale applications. Nowadays, it is mainly used for amino acid production in the food and feed industry i...

Die Induktion von Interleukin-10 in humanen T-Helfer-Zellen und seine transkriptionelle Regulation

Ahlers, Jonas (2017)

Die Produktion des anti-inflammatorischen Zytokins IL-10 von Th-Zellen ist ein wesentlicher Mechanismus zur Regulation von Immunantworten. Hierbei können professionelle regulatorische T-Zellen supp...

The induction and function of the transcription factor c-myc in macrophages during pneumococcal pneumonia and legionellosis

Kabus, Christin Sophia (2017)

For infectious diseases, effective defense mechanisms which constitute an efficient innate host response are the keys to eliminate invading pathogens. According to different studies, the pathogenic...

Application and de novo design of artificial gene switches for Aspergillus niger

Schütze, Tabea (2017)

Aspergillus niger ist ein filamentöser Pilz, der industriell für die Produktion von organischen Säuren und Proteinen genutzt wird. In den letzten Jahren konnte darüber hinaus die Produktion von hom...

Proteomics of a fuzzy organelle: interphase chromatin

Kustatscher, Georg; Hégarat, Nadia; Wills, Karen L. H.; Furlan, Cristina; Bukowski-Wills, Jimi-Carlo; Hochegger, Helfrid; Rappsilber, Juri (2014)

Chromatin proteins mediate replication, regulate expression, and ensure integrity of the genome. So far, a comprehensive inventory of interphase chromatin has not been determined. This is largely d...

Blind testing of cross-linking/mass spectrometry hybrid methods in CASP11

Schneider, Michael; Belsom, Adam; Rappsilber, Juri; Brock, Oliver (2016)

Hybrid approaches combine computational methods with experimental data. The information contained in the experimental data can be leveraged to probe the structure of proteins otherwise elusive to c...

Multiclassifier combinatorial proteomics of organelle shadows at the example of mitochondria in chromatin data

Kustatscher, Georg; Grabowski, Piotr; Rappsilber, Juri (2016)

Subcellular localization is an important aspect of protein function, but the protein composition of many intracellular compartments is poorly characterized. For example, many nuclear bodies are cha...

Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution

Davis, Matthew P.; Carrieri, Claudia; Saini, Harpreet K.; van Dongen, Stijn; Leonardi, Tommaso; Bussotti, Giovanni; Monahan, Jack M.; Auchynnikava, Tania; Bitetti, Angelo; Rappsilber, Juri; Allshire, Robin C.; Shkumatava, Alena; O'Carroll, Dónal; Enright, Anton J. (2017)

Spermatogenesis is associated with major and unique changes to chromosomes and chromatin. Here, we sought to understand the impact of these changes on spermatogenic transcriptomes. We show that lon...

Role of NOD2 and S100A8/S100A9 in the pathogenesis of Coxsackievirus B3-induced myocarditis

Müller, Irene (2017)

Cardiac inflammation plays a crucial role in Coxsackievirus B3 (CVB3)-induced myocarditis and is a consequence of viral-related cardiomyocyte injury, which activates the innate immune system. The n...

Autoantikörper-induzierte Effekte des Angiotensin II-Rezeptors Typ 1 und des Endothelinrezeptors Typ A auf humane periphere mononukleäre Zellen und ihre Relevanz bei der Pathogenese der systemischen Sklerose

Günther, Jeannine (2017)

Functional autoantibodies (aab) against the angiotensin II receptor type 1 (AT1R) and the endothelin 1 receptor type A (ETAR) have been identified in patients suffering from systemic sclerosis (SSc...

Partielle Charakterisierung der neuartigen humanen Polyomaviren HPyV9 und HPyV12

Korup-Schulz, Sarah-Verena (2017)

Im letzten Jahrzehnt wurden elf neue humane Polyomaviren (PyV) und zahlreiche tierische PyV identifiziert. Die Charakteristika dieser PyV wie Gewebetropismus, zelluläre Eintritts- und Infektionsmec...

Synthetic biomaterial microenvironments to modulate paracrine effects of mesenchymal stromal cells for skeletal muscle regeneration

Qazi, Taimoor Hasan (2017)

While skeletal muscles can recover from minor injuries, severe trauma can often induce irreversible structural damage such as extensive scar tissue formation and damaged muscle fibers. This leads t...

Tissue engineered cartilage: how hard can it be?

Kadler, Shirin (2017)

Für die Weiterentwicklung regenerativer Therapien sind humane in vitro Modelle aus Primärzellen entscheidend. Die Isolation und Expansion primärer Zellen zieht den Verlust der Gewebsspezifität nach...

Distribution of Dehalococcoidia in marine sediments and strategies for their enrichment

Algora, Camelia (2016)

The marine subsurface is one of the largest microbial habitats on Earth. Microbial community studies based on the 16S rRNA gene have revealed that bacteria of the class Dehalococcoidia, phylum Chlo...

Tumorzell-Stroma-Interaktionen beim Multiplen Myelom

Berenstein, Rimma (2016)

Multiple myeloma (MM) is a B-cell malignancy characterized by accumu- lation of malignant plasma cells (PC) within the bone marrow. Bone marrow mesenchymal stromal cells (BMMSCs) represent a cruci...

Investigation of experimental cell lines and non-invasive online sensor technologies in a 3D bioreactor system for extracorporeal liver support therapy

Richter, Marco (2016)

Liver transplantation is currently the only successful treatment to cure acute or acute-on-chronic liver failure. However, the number of patients waiting for a donor organ is constantly rising due ...

Colorectal cancer patient-derived xenograft (PDX) models as platform for drug screening, molecular and response analysis

Rivera, Maria (2016)

Appropriate preclinical in vivo models are of increasing importance and represent an essential tool in recent cancer research. Regarding the current developments in oncology, and particularly in pe...

The role of mast cells in the immune response against bacterial infections

Zimmermann, Carolin (2016)

Skin wound infections are a significant and increasing health problem, and antibiotic resistance is increasing. Mast cells have been shown to contribute to host defence responses in bacterial inf...

Characterization and identification of microbial contaminations and biofilm formation in metal-working-fluids

Langbein, Jennifer Edith (2016)

Microbial contamination in metal working fluids is a long known issue in fluid management with various effects. The microorganisms present pose a potential health hazards as pathogens are found fre...

Engineering of Aspergillus niger for the production of secondary metabolites

Richter, Lennart; Wanka, Franziska; Boecker, Simon; Storm, Dirk; Kurt, Tutku; Vural, Özlem; Süßmuth, Roderich; Meyer, Vera (2014)

Background: Filamentous fungi can each produce dozens of secondary metabolites which are attractive as therapeutics, drugs, antimicrobials, flavour compounds and other high-value chemicals. Further...