Fachgebiet Medizinische Biotechnologie
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9 Submissions in this community.

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Partielle Charakterisierung der neuartigen humanen Polyomaviren HPyV9 und HPyV12

Korup-Schulz, Sarah-Verena (2017)

Im letzten Jahrzehnt wurden elf neue humane Polyomaviren (PyV) und zahlreiche tierische PyV identifiziert. Die Charakteristika dieser PyV wie Gewebetropismus, zelluläre Eintritts- und Infektionsmec...

Synthetic biomaterial microenvironments to modulate paracrine effects of mesenchymal stromal cells for skeletal muscle regeneration

Qazi, Taimoor Hasan (2017)

While skeletal muscles can recover from minor injuries, severe trauma can often induce irreversible structural damage such as extensive scar tissue formation and damaged muscle fibers. This leads t...

Tissue engineered cartilage: how hard can it be?

Kadler, Shirin (2017)

Für die Weiterentwicklung regenerativer Therapien sind humane in vitro Modelle aus Primärzellen entscheidend. Die Isolation und Expansion primärer Zellen zieht den Verlust der Gewebsspezifität nach...

Investigation of experimental cell lines and non-invasive online sensor technologies in a 3D bioreactor system for extracorporeal liver support therapy

Richter, Marco (2016)

Liver transplantation is currently the only successful treatment to cure acute or acute-on-chronic liver failure. However, the number of patients waiting for a donor organ is constantly rising due ...

The role of mast cells in the immune response against bacterial infections

Zimmermann, Carolin (2016)

Skin wound infections are a significant and increasing health problem, and antibiotic resistance is increasing. Mast cells have been shown to contribute to host defence responses in bacterial inf...

Fluorescent optical fiber sensors for cell viability monitoring

Sergachev, Ilia; Rusanov, Alexander; Trushkin, Evgeny; Sakharov, Dmitry; Marx, Uwe; Tonevitsky, Alexander (2013)

A new simple method for non-invasive cell culture viability monitoring based on vital fluorescent stains is introduced, and its efficiency for long-term experiments on cells is demonstrated. In con...

Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput

Materne, Eva-Maria; Tonevitsky, Alexander G.; Marx, Uwe (2013)

Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxic...

Integrating biological vasculature into a multi-organ-chip microsystem

Schimek, Katharina; Busek, Mathias; Brincker, Sven; Groth, Benjamin; Hoffmann, Silke; Lauster, Roland; Lindner, Gerd; Lorenz, Alexandra; Menzel, Ulrike; Sonntag, Frank; Walles, Heike; Marx, Uwe; Horland, Reyk (2013)

A chip-based system mimicking the transport function of the human cardiovascular system has been established at minute but standardized microsystem scale. A peristaltic on-chip micropump generates ...

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, Ilka; Materne, Eva-Maria; Brincker, Sven; Süßbier, Ute; Frädrich, Caroline; Busek, Mathias; Sonntag, Frank; Sakharov, Dmitry A.; Trushkin, Evgeny V.; Tonevitsky, Alexander G.; Lauster, Roland; Marx, Uwe (2013)

Current in vitro and animal tests for drug development are failing to emulate the systemic organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we ...