Fachgebiet Organische Chemie

9 Items

Recent Submissions
Surface enhanced resonance Raman detection of a catalytic intermediate of DyP-type peroxidase

Todorovic, Smilja ; Hildebrandt, Peter ; Martins, Ligia O. (2015)

We report herein the vibrational spectroscopic characterisation of a catalytic intermediate formed by the reaction of H2O2 with DyP-type peroxidase immobilised on a biocompatible coated metal support. The SERR spectroscopic approach is of general applicability to other peroxidases which form relatively stable catalytic intermediates.

Ultrafast coherent oscillations reveal a reactive mode in the ring-opening reaction of fulgides

Slavov, C. ; Bellakbil, Nabil ; Wahl, J. ; Mayer, Kerstin ; Rück-Braun, Karola ; Burghardt, I. ; Wachtveitl, Josef ; Braun, M. (2015)

The ultrafast ring-opening reaction of photochromic fulgides proceeds via conical intersections to the ground state isomers involving activation barriers in the excited state. The coherent oscillations observed in the femtosecond transient absorption signal of a methyl-substituted indolylfulgide were analysed in the framework of vibrational wavepackets to expose a dominant low-frequency mode at...

Involvement of secondary metabolites in the pathogenesis of the American foulbrood of honey bees caused by Paenibacillus larvae

Müller, Sebastian ; García-Gonzalez, Eva ; Genersch, Elke ; Süssmuth, Roderich D. (2015)

Covering: 2011 to end of 2014 The Gram-positive, spore-forming bacterium Paenibacillus larvae (P. larvae) is the causative agent of the epizootic American Foulbrood (AFB), a fatal brood disease of the western honey bee (Apis mellifera). AFB is one of the most destructive honey bee diseases since it is not only lethal for infected larvae but also for the diseased colonies. Due to the high impact...

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

Al Toma, Rashed S. ; Brieke, Clara ; Cryle, Max J. ; Süssmuth, Roderich D. (2015)

Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and ph...

Activation of boron–boron, tin–silicon, and tin–tin bonds

Pareek, Manish (2017)

Die vorliegende Arbeit fokussiert sich auf die Aktivierung von Interelementbindungen der Elemente Bor, Silicium und Zinn. Der erste Teil dieser Arbeit beschreibt die Aktivierung von Diborbindungen durch oxidative Addition von Bor–Bor-Bindungen an niedervalente Platin(0)-Katalysatoren. Die Übertragung dieser aktivierten Diborspezies auf ungesättigte Kohlenstoff–Kohlenstoff-Bindungen ist in der L...

Bacillus subtilis as heterologous host for the secretory production of the non-ribosomal cyclodepsipeptide enniatin

Zobel, Sophia ; Kumpfmüller, Jana ; Süssmuth Roderich D. ; Schweder, Thomas (2014)

The heterologous expression of genes or gene clusters in microbial hosts, followed by metabolic engineering of biosynthetic pathways, is key to access industrially and pharmaceutically relevant compounds in an economically affordable and sustainable manner. Therefore, platforms need to be developed, which provide tools for the controlled synthesis of bioactive compounds. The Gram-positive bacte...

Synthese photochromer Aminosäuren und deren Einbau in Peptidstrukturen

Kitzig, Sebastian (2017)

Die gesteuerte Untersuchung biochemischer Vorgänge und Zusammenhänge zur Behandlung von diversen Krankheitsbildern ist eines der Ziele der modernen Forschung. Dabei erlaubt die Verwendung von photoschaltbaren Biomolekülen die Veränderung von deren Struktur durch die Bestrahlung mit Licht und entspricht somit einer minimal- bis nichtinvasiven Methode. So können Sekundärstruktur-elemente in Pepti...

Asymmetrische Katalyse mit Siliciumnukleophilen aus verschiedenen Siliciumquellen unter Verwendung präformierter NHC-Kupfer(I)-Komplexe

Hensel, Alexander (2016)

Die vorliegende Dissertation widmet sich der katalytischen Erzeugung siliciumbasierter, cupratartiger Nukleophile und deren Anwendung auf dem Gebiet der asymmetrischen Kohlenstoff–Silicium-Bindungsknüpfung. Unabhängig von der Wahl der Siliciumquelle wurden unter Verwendung eines chiralen NHC–Kupfer(I)-Komplexes (NHC = N-heterocyclisches-Carben) verschiedene Akzeptoren hoch enantioselektiv in di...

Polyoxometalate-stabilized, water dispersible Fe2Pt magnetic nanoparticles

Seemann, K. M. ; Bauer, A. ; Kindervater, J. ; Meyer, M. ; Besson, C. ; Luysberg, M. ; Durkin, P. ; Pyckhout-Hintzen, W. ; Budisa, Nediljko ; Georgii, R. ; Schneider, C. M. ; Kögerler, P. (2013)

Magnetic Fe2Pt core–shell nanoparticles with 2 nm cores were synthesized with a monolayer coating of silicotungstate Keggin clusters. The core–shell composition is substantiated by structural analysis performed using high-resolution scanning transmission electron microscopy (HR-STEM) and small angle X-ray scattering (SAXS) in a liquid suspension. The molecular metal oxide cluster shell introduc...