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4 Submissions in this community.

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Adaptation of E. coli towards tryptophan analog usage

Oehm, Stefan (2016)

The presented study set out to change the amino acid set of the genetic code in two different Trp-auxotrophic E. coli strains with the help of the serial transfer regime under constant evolutionary...

Evaluation of bicinchoninic acid as a ligand for copper(I)-catalyzed azide-alkyne bioconjugations

Christen, Erik H.; Gübeli, Raphael J.; Kaufmann, Beate; Merkel, Lars; Schoenmakers, Ronald; Budisa, Nediljko; Fussenegger, Martin; Weber, Wilfried; Wiltschi, Birgit (2012)

The Cu(I)-catalyzed cycloaddition of terminal azides and alkynes (click chemistry) represents a highly specific reaction for the functionalization of biomolecules with chemical moieties such as dye...

Organic fluorine as a polypeptide building element: in vivo expression of fluorinated peptides, proteins and proteomes

Merkel, L.; Budisa, Nediljko (2012)

Traditionally, the biological fluorination of complex biological systems like proteins is achieved through substitution of canonical amino acids or addition of fluorinated amino acids in the contex...

Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

Acevedo-Rocha, Carlos G.; Hoesl, Michael G.; Nehring, Sebastian; Royter, Marina; Wolschner, Christina; Wiltschi, Birgit; Antranikian, Garabed; Budisa, Nediljko (2013)

The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to ...