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Main Title: Chiral amides via copper-catalysed enantioselective conjugate addition
Author(s): Schoonen, Anne K.
Angeles Fernandez-Ibanez, M.
Fananas-Mastral, Martin
Teichert, Johannes F.
Feringa, Ben L.
Type: Article
Language Code: en
Abstract: A highly enantioselective one pot procedure for the synthesis of β-substituted amides was developed starting from the corresponding α,β-unsaturated esters. This new methodology is based on the copper-catalysed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters and subsequent direct formation of amides by quenching the corresponding enolates with different amines. Various primary and secondary amines bearing alkyl or aryl substituents can be used giving rise to a large variety of β-substituted amides with excellent enantioselectivities.
Issue Date: 2014
Date Available: 21-Jun-2016
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Journal Title: Organic & biomolecular chemistry : OBC
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 12
Issue: 1
Publisher DOI: 10.1039/c3ob41923a
Page Start: 36
Page End: 41
EISSN: 1477-0539
ISSN: 1477-0520
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:Inst. Chemie » Publications

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