Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-5215
Main Title: Recent advances in the field of bioactive tetronates
Author(s): Vieweg, Laura
Reichau, Sebastian
Schobert, Rainer
Leadlay, Peter F.
Süssmuth, Roderich D.
Type: Article
Language Code: en
Abstract: Covering: up to mid-2014 Over the last several decades, the number of pharmacologically active natural products has significantly increased and several natural product families have taken shape. This review highlights the family of tetronate and spirotetronate compounds, which show a vast structural and functional diversity. The rapid growth of this group has created the need for a comprehensive overview and classification system, which we have devised based on structural characteristics. An updated overview is provided based on known tetronates, intended to spur further research in this field by identifying common structural features and general principles of their biosynthesis. We also compare a selection of chemical syntheses of representative compounds belonging to individual subtypes, both in terms of their efficiency as well as the extent to which they are biomimetic. This review also summarizes progress in unraveling some of the principles underlying the potent and varied bioactivities of natural tetronate antibiotics, and in identifying and better understanding their structure–activity relationships and modes of action.
URI: http://depositonce.tu-berlin.de/handle/11303/5586
http://dx.doi.org/10.14279/depositonce-5215
Issue Date: 2014
Date Available: 22-Jun-2016
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, EXC 314, Unifying Concepts in Catalysis
Creative Commons License: https://creativecommons.org/licenses/by/3.0/
Journal Title: Natural product reports
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 31
Issue: 11
Publisher DOI: 10.1039/c4np00015c
Page Start: 1554
Page End: 1584
EISSN: 0265-0568
Appears in Collections:Technische Universität Berlin » Fakultäten & Zentralinstitute » Fakultät 2 Mathematik und Naturwissenschaften » Institut für Chemie » Publications

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