Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-5229
Main Title: Softening of phospholipid membranes by the adhesion of silica nanoparticles - as seen by neutron spin-echo (NSE)
Author(s): Hoffmann, Ingo
Michel, Raphael
Sharp, Melissa
Holderer, Olaf
Appavou, Marie-Sousai
Polzer, Frank
Farago, Bela
Gradzielski, Michael
Type: Article
Language Code: en
Abstract: The interactions between nanoparticles and vesicles are of significant interest both from a fundamental as well as from a practical point of view, as vesicles can serve as a model system for cell membranes. Accordingly the effect of nanoparticles that bind to the vesicle bilayer is very important with respect to understanding their biological impact and also may shed some light on the mechanisms behind the effect of nanotoxicity. In this study we have investigated the influence of small adsorbed silica nanoparticles (SiNPs) on the structure of zwitterionic DOPC vesicles. By a combination of SANS, cryo-TEM, and DLS, we observed that the SiNPs are bound to the outer vesicle surface without significantly affecting the vesicle structure. Most interestingly, by means of neutron spin-echo (NSE) local bilayer fluctuations were studied and one finds a small but marked decrease of the membrane rigidity upon binding of the nanoparticles. This surprising finding may be a relevant aspect for the further understanding of the effects that nanoparticles have on phospholipid bilayers.
URI: http://depositonce.tu-berlin.de/handle/11303/5600
http://dx.doi.org/10.14279/depositonce-5229
Issue Date: 2014
Date Available: 22-Jun-2016
DDC Class: 600 Technik, Technologie
Sponsor/Funder: DFG, GRK 1524, Self-Assembled Soft-Matter Nanostructures at Interfaces
BMBF, 05K10KT1, NanoSOFT: Teilprojekt 2: Neutronen Spin-Echo Experimente zur Untersuchung komplexer Soft-Matter Systeme mit extremer Präzission
Creative Commons License: https://creativecommons.org/licenses/by/3.0/
Journal Title: Nanoscale
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 6
Issue: 12
Publisher DOI: 10.1039/c4nr00774c
Page Start: 6945
Page End: 6952
EISSN: 2040-3364
Appears in Collections:Technische Universität Berlin » Fakultäten & Zentralinstitute » Fakultät 2 Mathematik und Naturwissenschaften » Institut für Chemie » Publications

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