Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-5242
Main Title: Modeling crawling cell movement on soft engineered substrates
Author(s): Löber, Jakob
Ziebert, Falko
Aranson, Igor S.
Type: Article
Language Code: en
Abstract: Self-propelled motion, emerging spontaneously or in response to external cues, is a hallmark of living organisms. Systems of self-propelled synthetic particles are also relevant for multiple applications, from targeted drug delivery to the design of self-healing materials. Self-propulsion relies on the force transfer to the surrounding. While self-propelled swimming in the bulk of liquids is fairly well characterized, many open questions remain in our understanding of self-propelled motion along substrates, such as in the case of crawling cells or related biomimetic objects. How is the force transfer organized and how does it interplay with the deformability of the moving object and the substrate? How do the spatially dependent traction distribution and adhesion dynamics give rise to complex cell behavior? How can we engineer a specific cell response on synthetic compliant substrates? Here we generalize our recently developed model for a crawling cell by incorporating locally resolved traction forces and substrate deformations. The model captures the generic structure of the traction force distribution and faithfully reproduces experimental observations, like the response of a cell on a gradient in substrate elasticity (durotaxis). It also exhibits complex modes of cell movement such as “bipedal” motion. Our work may guide experiments on cell traction force microscopy and substrate-based cell sorting and can be helpful for the design of biomimetic “crawlers” and active and reconfigurable self-healing materials.
URI: http://depositonce.tu-berlin.de/handle/11303/5613
http://dx.doi.org/10.14279/depositonce-5242
Issue Date: 2014
Date Available: 23-Jun-2016
DDC Class: 530 Physik
Sponsor/Funder: DFG, GRK 1558, Kollektive Dynamik im Nichtgleichgewicht: in kondensierter Materie und biologischen Systemen
Usage rights: Terms of German Copyright Law
Journal Title: Soft matter
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 10
Issue: 9
Publisher DOI: 10.1039/c3sm51597d
Page Start: 1365
Page End: 1373
EISSN: 1744-6848
ISSN: 1744-683X
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:Technische Universität Berlin » Fakultäten & Zentralinstitute » Fakultät 2 Mathematik und Naturwissenschaften » Institut für Theoretische Physik » Publications

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