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Main Title: Arg-Thz is a minimal substrate for the N-alpha,N-alpha-arginyl methyltransferase involved in the biosynthesis of plantazolicin
Author(s): Piwowarska, Natalia A.
Banala, Srinivas
Overkleeft, Hermen S.
Süßmuth, Roderich D.
Type: Article
Language Code: en
Abstract: The final biosynthetic step towards plantazolicin (PZN) comprises Nα,Nα-arginyl methyltransferase (PznL) mediated N-terminal bismethylation. We show that PznL processes truncated desmethyl-plantazolicin analogues, but only those with an N-terminal guanidine side chain derived from arginine. PznL specificity, which is narrow, depends on the side chain of the N-terminal amino acid linked to an azole, and not so much on the number of azoles.
Issue Date: 2013
Date Available: 24-Jun-2016
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, EXC 314, Unifying Concepts in Catalysis
Journal Title: Chemical communications
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 49
Issue: 91
Publisher DOI: 10.1039/c3cc45898a
Page Start: 10703
Page End: 10705
EISSN: 1359-7345
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:Inst. Chemie » Publications

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