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Main Title: Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput
Author(s): Materne, Eva-Maria
Tonevitsky, Alexander G.
Marx, Uwe
Type: Article
Language Code: en
Abstract: Drug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxicity test dilemma have recently risen to a historic level based on the latest progress in human microfluidic tissue culture devices. Chip-based human liver equivalents are envisaged to identify liver toxic agents regularly undiscovered by current test procedures at industrial throughput. In this review, we focus on advanced microfluidic microscale liver equivalents, appraising them against the level of architectural and, consequently, functional identity with their human counterpart in vivo. We emphasise the inherent relationship between human liver architecture and its drug-induced injury. Furthermore, we plot the current socio-economic drug development environment against the possible value such systems may add. Finally, we try to sketch a forecast for translational innovations in the field.
Issue Date: 2013
Date Available: 24-Jun-2016
DDC Class: 004 Datenverarbeitung; Informatik
570 Biowissenschaften; Biologie
540 Chemie und zugeordnete Wissenschaften
Journal Title: Lab on a chip : miniaturisation for chemistry and biology
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 13
Issue: 18
Publisher DOI: 10.1039/c3lc50240f
Page Start: 3481
Page End: 3495
EISSN: 1473-0197
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:FG Medizinische Biotechnologie » Publications

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