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Main Title: Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
Author(s): Ataç, Beren
Wagner, Ilka
Horland, Reyk
Lauster, Roland
Marx, Uwe
Tonevitsky, Alexander G.
Azar, Reza P.
Lindner, Gerd
Type: Article
Language Code: en
Abstract: Substantial progress has been achieved over the last few decades in the development of skin equivalents to model the skin as an organ. However, their static culture still limits the emulation of essential physiological properties crucial for toxicity testing and compound screening. Here, we describe a dynamically perfused chip-based bioreactor platform capable of applying variable mechanical shear stress and extending culture periods. This leads to improvements of culture conditions for integrated in vitro skin models, ex vivo skin organ cultures and biopsies of single hair follicular units.
Issue Date: 2013
Date Available: 24-Jun-2016
DDC Class: 004 Datenverarbeitung; Informatik
570 Biowissenschaften; Biologie
540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: BMBF, 0315569, GO-Bio 3: Multi-Organ-Bioreaktoren für die prädiktive Substanztestung im Chipformat
DFG, GSC 203, Berlin-Brandenburg School for Regenerative Therapies
Journal Title: Lab on a chip : miniaturisation for chemistry and biology
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 13
Issue: 18
Publisher DOI: 10.1039/c3lc50227a
Page Start: 3555
Page End: 3561
EISSN: 1473-0197
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:Inst. Biotechnologie » Publications

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