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Main Title: Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments
Author(s): Acevedo-Rocha, Carlos G.
Hoesl, Michael G.
Nehring, Sebastian
Royter, Marina
Wolschner, Christina
Wiltschi, Birgit
Antranikian, Garabed
Budisa, Nediljko
Type: Article
Language Code: en
Abstract: The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments.
Issue Date: 2013
Date Available: 27-Jun-2016
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, EXC 314, Unifying Concepts in Catalysis
Journal Title: Catalysis science & technology : a multidisciplinary journal focussing on all fundamental science and technological aspects of catalysis
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 3
Issue: 5
Publisher DOI: 10.1039/c3cy20712a
Page Start: 1198
Page End: 1201
EISSN: 2044-4753
Appears in Collections:FG Biokatalyse » Publications

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