Please use this identifier to cite or link to this item:
Main Title: Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds
Author(s): Artner, Lukas M.
Merkel, Lars
Bohlke, Nina
Beceren-Braun, Figen
Weise, Christoph
Dernedde, Jens
Budisa, Nediljko
Hackenberger, Christian P. R.
Type: Article
Language Code: en
Abstract: A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands.
Issue Date: 2012
Date Available: 28-Jun-2016
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, SFB 765, Multivalenz als chemisches Organisations- und Wirkprinzip: Neue Architekturen, Funktionen und Anwendungen
Journal Title: Chemical communications
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 48
Issue: 4
Publisher DOI: 10.1039/c1cc16039g
Page Start: 522
Page End: 524
EISSN: 1359-7345
Notes: Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
Appears in Collections:Inst. Chemie » Publications

Files in This Item:
File Description SizeFormat 
c1cc16039g.pdf1.81 MBAdobe PDFThumbnail

Items in DepositOnce are protected by copyright, with all rights reserved, unless otherwise indicated.