Fak. 3 Prozesswissenschaften

1098 Items

Recent Submissions
Construction of an improved Aspergillus niger platform for enhanced glucoamylase secretion

Fiedler, Markus R. M. ; Barthel, Lars ; Kubisch, Christin ; Nai, Corrado ; Meyer, Vera (2018-06-16)

Background The lifestyle of filamentous fungi depends on the secretion of hydrolytic enzymes into the surrounding medium, which degrade polymeric substances into monomers that are then taken up to sustain metabolism. This feature has been exploited in biotechnology to establish platform strains with high secretory capacity including Aspergillus niger. The accepted paradigm is that proteins bec...

The PSS quality framework for solar home systems

Kebir, Noara Zohra ; Philipp, Daniel (2016-08)

In September 2015, the United Nations General Assembly has adopted the Sustainable Development Goals; they include SDG 7 targeting universal access to electricity by 2030. Reaching this goal implies huge investments in generation capacity, grid extension and densification. However, according to the International Energy Agency, 70% of the world's population currently excluded from electricity se...

Microscopic aspects of ageing in Al-Mg-Si alloys

Madanat, Mazen (2018)

Al-Mg-Si alloys with a low solute content (0.4 %Mg, 0.4 %Si) and higher contents (Mg+Si=1.4 %, all in wt.%) were solutionized, quenched and then either artificially aged (AA) at 180 °C or naturally pre-aged (NPA) for 2 weeks at room temperature and then reverse aged (RA) at 250 °C. Subsequently, positron annihilation lifetime spectroscopy was applied with the objective of obtaining information ...

Optimierung der normgerechten Intensitätsbewertung und Untersuchung weiterer Referenzgerüche zur Qualitätssicherung

Brosig, Laura (2018)

For energy saving purposes buildings are constructed increasingly airtight. Due to insufficient ventilation emissions from building materials and products might accumulate indoors. Not only emissions of volatile organic compounds (VOC) may cause impact on health and well-being of occupants but odours as well. Therefore, their perceived intensity can be assessed based on acetone as reference sub...

Dampferzeugeroptimierung zur Abwärmenutzung mittels Dampfkraftprozess an mobilen Verbrennungsmotoren

Stinner, Karl (2018)

Die im Kraftstoff gespeicherte Energie wird auch bei modernsten Verbrennungsmotoren nur zu ungefähr 30% in mechanische Antriebsleistung umgewandelt. Der größere Teil geht als Abwärme an die Umgebung verloren. Der daraus resultierende mittlere Wirkungsgrad des Pkw-Verbrennungsmotors kann jedoch durch teilweise Umwandlung der thermischen Energie erhöht werden. Hierzu kann die im Abgas verbleiben...

Identifikation und Detektion von Indikatororganismen in technischen Systemen

Schleicher, Maria (2018)

Wasser ist ein essentieller Grundstoff für alle Organismen der Erde und damit einer der wichtigsten Ressourcen. Die Forschung auf dem Gebiet der Wasserwiederverwendung und Wasserrückgewinnung ist von enormer Bedeutung. Durch die Teilnahme an einem internationalen Forschungsprojekt entstand die Motivation, Überwachungs- und Kontrolloptionen für Desinfektionsprozesse weiterzuentwickeln. In der ko...

G9a/GLP complex maintains imprinted DNA methylation in embryonic stem cells

Zhang, Tuo ; Termanis, Ausma ; Özkan, Burak ; Bao, Xun X. ; Culley, Jayne ; de Lima Alves, Flavia ; Rappsilber, Juri ; Ramsahoye, Bernard ; Stancheva, Irina (2016-03-24)

DNA methylation at imprinting control regions (ICRs) is established in gametes in a sex-specific manner and has to be stably maintained during development and in somatic cells to ensure the correct monoallelic expression of imprinted genes. In addition to DNA methylation, the ICRs are marked by allele-specific histone modifications. Whether these marks are essential for maintenance of genomic i...

Evaluation of an energy- and exergy-based generic modeling approach of combined heat and power plants

Mollenhauer, Eike ; Christidis, Andreas ; Tsatsaronis, George (2016-02-29)

Reduced models of combined heat and power plants are required for different applications. Among other usages, they are implemented as mixed integer linear programs (MILP) in energy market models or price-based unit commitment problems to study the economic feasibility and optimal operation strategies of different units. Generic models are particularly useful when limited information is availabl...

HisB as novel selection marker for gene targeting approaches in Aspergillus niger

Fiedler, Markus R. M. ; Gensheimer, Tarek ; Kubisch, Christin ; Meyer, Vera (2017-03-08)

Background For Aspergillus niger, a broad set of auxotrophic and dominant resistance markers is available. However, only few offer targeted modification of a gene of interest into or at a genomic locus of choice, which hampers functional genomics studies. We thus aimed to extend the available set by generating a histidine auxotrophic strain with a characterized hisB locus for targeted gene int...

Waste prevention for sustainable resource and waste management

Sakai, Shin-ichi ; Yano, Yasuhiro ; Asari, Misuzu ; Yanagawa, Ritsuki ; Matsuda, Takeshi ; Yoshida, Hideto ; Yamada, Tetsuji ; Kajiwara, Natsuko ; Suzuki, Go ; Kunisue, Tatsuya ; Takahashi, Shin ; Tomoda, Keijiro ; Wuttke, Joachim ; Mählitz, Paul ; Rotter, Vera Susanne ; Grosso, Mario ; Astrup, Thomas Fruergaard ; Cleary, Julian ; Oh, Gil-Jong ; Liu, Lili ; Li, Jinhui ; Ma, Hwong-wen ; Chi, Ngo Kim ; Moore, Stephen (2017-02-21)

Although the 2Rs (reduce and reuse) are considered high-priority approaches, there has not been enough quantitative research on effective 2R management. The purpose of this paper is to provide information obtained through the International Workshop in Kyoto, Japan, on 11–13 November 2015, which included invited experts and researchers in several countries who were in charge of 3R policies, and ...

The WULCA consensus characterization model for water scarcity footprints: assessing impacts of water consumption based on available water remaining (AWARE)

Boulay, Anne-Marie ; Bare, Jane ; Benini, Lorenzo ; Berger, Markus ; Lathuillière, Michael J. ; Manzardo, Alessandro ; Margni, Manuele ; Motoshita, Masaharu ; Núñez, Montserrat ; Pastor, Amandine Valerie ; Ridoutt, Bradley ; Oki, Taikan ; Worbe, Sebastien ; Pfister, Stephan (2017-06-08)

Purpose Life cycle assessment (LCA) has been used to assess freshwater-related impacts according to a new water footprint framework formalized in the ISO 14046 standard. To date, no consensus-based approach exists for applying this standard and results are not always comparable when different scarcity or stress indicators are used for characterization of impacts. This paper presents the outcom...

Kicking against the PRCs

Liang, Shih Chieh ; Hartwig, Ben ; Perera, Pumi ; Mora-García, Santiago ; Leau, Erica de ; Thornton, Harry ; Lima Alves, Flavia de ; Rappsilber, Juri ; Yang, Suxin ; James, Geo Velikkakam ; Schneeberger, Korbinian ; Finnegan, E. Jean ; Turck, Franziska ; Goodrich, Justin (2015)

The Polycomb group (PcG) and trithorax group (trxG) genes play crucial roles in development by regulating expression of homeotic and other genes controlling cell fate. Both groups catalyse modifications of chromatin, particularly histone methylation, leading to epigenetic changes that affect gene activity. The trxG antagonizes the function of PcG genes by activating PcG target genes, and conseq...

Mechanical properties in crumple-formed paper derived materials subjected to compression

Hanaor, D.A.H. ; Flores Johnson, E.A. ; Wang, S. ; Quach, S. ; Dela-Torre, K.N. ; Gan, Y. ; Shen, L. (2017-06)

The crumpling of precursor materials to form dense three dimensional geometries offers an attractive route towards the utilisation of minor-value waste materials. Crumple-forming results in a mesostructured system in which mechanical properties of the material are governed by complex cross-scale deformation mechanisms. Here we investigate the physical and mechanical properties of dense compacte...

Anti-adenoviral artificial microRNAs Expressed from AAV9 vectors inhibit human adenovirus infection in immunosuppressed Syrian hamsters

Schaar, Katrin ; Geisler, Anja ; Kraus, Milena ; Pinkert, Sandra ; Pryshliak, Markian ; Spencer, Jacqueline F. ; Tollefson, Ann E. ; Ying, Baoling ; Kurreck, Jens ; Wold, William S. ; Klopfleisch, Robert ; Toth, Karoly ; Fechner, Henry (2017-09)

Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral efficiency are not clinically approved and have limited efficacy. Small double-stranded RNAs that induce RNAi represent a new class of promising anti-adenoviral therapeutics. However, as yet, their efficiency to treat hAd5 infections has only be...

Hepatitis E virus superinfection and clinical progression in hepatitis B patients

Hoan, Nghiem Xuan ; Tong, Hoang Van ; Hecht, Nicole ; Sy, Bui Tien ; Marcinek, Patrick ; Meyer, Christian G. ; Song, Le Huu ; Toan, Nguyen Linh ; Kurreck, Jens ; Kremsner, Peter G. ; Bock, C-Thomas ; Velavan, Thirumalaisamy P. (2015)

Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-r...

How a fungus shapes biotechnology: 100 years of Aspergillus niger research

Cairns, Timothy C. ; Nai, Corrado ; Meyer, Vera (2018-05-24)

In 1917, a food chemist named James Currie made a promising discovery: any strain of the filamentous mould Aspergillus niger would produce high concentrations of citric acid when grown in sugar medium. This tricarboxylic acid, which we now know is an intermediate of the Krebs cycle, had previously been extracted from citrus fruits for applications in food and beverage production. Two years afte...

The Sustainable Child Development Index (SCDI) for countries

Chang, Ya-Ju ; Lehmann, Annekatrin ; Winter, Lisa ; Finkbeiner, Matthias (2018-05-14)

Despite the relevance of children in inheriting and shaping society, an index assessing sustainable development with a focus on children is missing. To tackle this gap, this study established the Sustainable Child Development Index (SCDI) by considering child development topics in the context of inter-generational equity and applying indicators with available statistical data on country level. ...

Conditional expression of the small GTPase ArfA impacts secretion, morphology, growth, and actin ring position in Aspergillus niger

Fiedler, Markus R. M. ; Cairns, Timothy C. ; Koch, Oliver ; Kubisch, Christin ; Meyer, Vera (2018-05-08)

In filamentous fungi, growth and protein secretion occurs predominantly at the tip of long, thread like cells termed hyphae. This requires coordinated regulation of multiple processes, including vesicle trafficking, exocytosis, and endocytosis, which are facilitated by a complex cytoskeletal apparatus. In this study, functional analyses of the small GTPase ArfA from Aspergillus niger demonstrat...

Geregelte Strömungskontrolle einer Statorkaskade mit Seitenwand- und Hinterkantenaktuation

Kiesner, Matthias (2018)

Die Steigerung des Wirkungsgrades von Gasturbinen ist ein wichtiges Entwicklungs- und Forschungsziel. Durch die große Stückzahl der weltweit im Energie- und Transportsektor eingesetzten Gasturbinen ist das Potential für eine Reduktion der Treibhausgasemissionen enorm. Aktuell wird eine neue Technologie erforscht, die einen Wechsel von der konventionellen isobaren Verbrennung zu einer isochoren ...

Energieeffiziente Gärrestaufbereitung

Gienau, Tobias (2018)

Aufgrund der zunehmenden Überdüngung landwirtschaftlicher Flächen durch Wirtschaftsdünger und Gärreste aus Biogasanlagen wird eine ökonomische und ökologische Vollaufbereitungstechnik zur Separation der Nährstoffe und zur Gewinnung von Prozesswasser aus Gärresten und Güllen benötigt. Das Vollaufbereitungsverfahren zur Düngemittelrückgewinnung durch mehrstufige Fest-/ Flüssigtrennung und Membran...