Fak. 3 Prozesswissenschaften

1116 Items

Recent Submissions
Theoretische Untersuchung des Wärme- und Stoffübergangs am laminaren Fallfilm

Mittermaier, Martin (2018)

In this thesis a model is presented describing a laminar film flow over a vertical isothermal plate while heat and mass transfer is occurring. Most common assumptions, such as constant property data and constant film thickness, have been cancelled. The hydrodynamic model results in longitudinal and transversal velocity components and their evolution in the entrance region. Heat and mass transfe...

Strategies to increase turbidity in beverage emulsions

Linke, Christina (2018)

Carbonisierte Erfrischungsgetränke enthalten für ein trübes Erscheinungsbild häufig Getränkeemulsionen. Diese sogenannten „Clouds“ sollen die Natürlichkeit fruchtbasierter Getränke unterstreichen. Ziel der vorliegenden Arbeit war es, Strategien zu entwickeln, die Trübkraft von Getränkeemulsionen zu erhöhen. Um dies zu erreichen, musste zunächst eine Korrelation zwischen der optischen Wahrnehmun...

Preparation, characterization and electrical properties of nanocomposites based on hyperbranched polymers

Omara, Shereen Said Shabaan (2018)

Nanocomposites based on hyperbranched polymers (HBPs) and layered silicates as nanofillers are a relatively new class of nanocomposites. Due to their unique physical/chemical properties, they have attracted scientific interests. This study provides to a better understand the structure-dynamics-properties relationship, for different types of HBP/ kaolinite (Ka) nanocomposites. Two different me...

Development of eukaryotic cell-free systems based on Chinese hamster ovary cells for the production of "difficult-to-express" proteins

Thoring, Lena (2018)

Nowadays, recombinant protein production plays a pivotal role for the manufacturing of biopharmaceuticals. A variety of in vivo production systems are available originating from eukaryotic and prokaryotic hosts, whereby Chinese Hamster Ovary cells (CHO cells) are one of the main production cell line for complex, mammalian proteins. Limitations of cell based protein production systems are often ...

Identification of hypoxia-specific anti-cancer drugs using an in vitro spheroid model

Klutzny, Saskia (2018)

Cancer is among the leading causes of morbidity and mortality worldwide and the effectiveness of novel treatment approaches is often limited by the development of drug resistance. Owing to the rapid growth, high metabolic rates and lagging or insufficient neo-angiogenesis, many solid tumors are characterized by large regions of hypoxia. Tumor hypoxia is a main determinant for resistance develop...

Assessment of abiotic and biotic resource use for products and regions in the context of sustainable development

Bach, Vanessa (2018)

Resources are the basis for a thriving industrial and technological development and therefore for prosperity of present and future generations. With increasing resource use, challenges with regard to (physical and socio-economic) availability of abiotic and biotic resources and raw materials, pollution of the environment as well as social impacts associated with resource extraction and use aris...

Optimierung der passiven Dialyse zur Inline-Probenvorbereitung in der Ionenchromatographie

Markeviciute, Inga (2018)

The focus of this Ph.D. Thesis is the instrumental improvement and optimization of a commercially available system for stopped-flow dialysis in hyphenation with ion chromatography. The two main aspects of the present thesis are the application of dialysis membranes permitting better separation of potentially interfering compounds and shortening of the dialysis time required to achieve concentra...

Analytische und numerische Modellbildung zur Vermeidung von Rückströmungen aufgrund von Störgrößen in Reinräumen

Brandt, Stefan (2018)

In der vorliegenden Arbeit werden Funktionen und Berechnungen von Rückströmungen aufgrund von Zustandsänderungen der Volumenstromstellglieder in Reinräumen dargestellt. Die Zustandsänderungen werden in aktive und passive Störgrößen unterteilt. Ausgehend von den Ergebnissen der Untersuchungen werden Berechnungsvorschriften zum Auftreten von Rückströmungen aufgrund von Störgrößen in Reinräumen be...

Effect of dispersed hydrophilic silicon dioxide nanoparticles on batch adsorption of benzoic acid from aqueous solution using modified natural vermiculite: An equilibrium study

Pouya, Ehsan Sadeghi ; Abolghasemi, Hossein ; Fatoorehchi, Hooman ; Rasem, Bettina ; Hashemi, Seyed Jalaledin (2016-10-11)

The equilibrium adsorption of benzoic acid from an aqueous medium on a natural vermiculite-based adsorbent was studied in the presence and absence of hydrophilic silicon dioxide nanoparticles in batchwise mode. The adsorbent was prepared through grinding natural vermiculite in a laboratory vibratory disk mill and the surfactant modification of ground vermiculite by cetyltrimethylammonium bromid...

Recommendations guidelines on the key information to be reported in studies of application of PEF technology in food and biotechnological processes

Raso, Javier ; Frey, Wolfgang ; Ferrari, Giovanna ; Pataro, Gianpiero ; Knorr, Dietrich ; Teissie, Justin ; Miklavčič, Damijan (2016-08-04)

The application of pulsed electric field (PEF) technology as a non-thermal cell membrane permeabilization treatment, was widely demonstrated widely to be effective in microbial inactivation studies, as well as to increase the rates of heat and mass transfer phenomena in food and biotechnological processes (drying, osmotic treatment, freezing, extraction, and diffusion). Nevertheless, most publi...

Heterologous biosynthesis, modifications and structural characterization of ruminococcin-A, a lanthipeptide from the gut bacterium Ruminococcus gnavus E1, in Escherichia coli

Ongey, Elvis Legala ; Giessmann, Robert ; Fons, Michel ; Rappsilber, Juri ; Adrian, Lorenz ; Neubauer, Peter (2018-07-26)

Ruminococcin A (RumA) is a lanthipeptide with high activity against pathogenic clostridia and is naturally produced by the strict anaerobic bacterium Ruminococcus gnavus E1, isolated from human intestine. Cultivating R. gnavus E1 is challenging, limiting high-quality production, further biotechnological development and therapeutic exploitation of RumA. To supply an alternative production system...

P45 IL-2 therapy reduces renal inflammation and cellular activity of intrarenal CD4+ conventional T cells in lupus prone mice with active lupus nephritis

Rose, A. ; von Spee-Mayer, C. ; Kloke, Lutz ; Wu, K. ; Enghard, P. ; Kühl, A. ; Humrich, J.Y. ; Riemekasten, G. (2016-11)

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Bioinspired designs, molecular premise and tools for evaluating the ecological importance of antimicrobial peptides

Ongey, Elvis Legala ; Pflugmacher, Stephan ; Neubauer, Peter (2018-07-10)

This review article provides an overview of recent developments in antimicrobial peptides (AMPs), summarizing structural diversity, potential new applications, activity targets and microbial killing responses in general. The use of artificial and natural AMPs as templates for rational design of peptidomimetics are also discussed and some strategies are put forward to curtail cytotoxic effects a...

Real-time monitoring of the budding index in Saccharomyces cerevisiae batch cultivations with in situ microscopy

Marbà-Ardébol, Anna-Maria ; Emmerich, Jörn ; Muthig, Michael ; Neubauer, Peter ; Junne, Stefan (2018-05-15)

Background The morphology of yeast cells changes during budding, depending on the growth rate and cultivation conditions. A photo-optical microscope was adapted and used to observe such morphological changes of individual cells directly in the cell suspension. In order to obtain statistically representative samples of the population without the influence of sampling, in situ microscopy (ISM) w...

Application options of the Sustainable Child Development Index (SCDI) – assessing the status of sustainable development and establishing social impact pathways

Chang, Ya-Ju ; Lehmann, Annekatrin ; Winter, Lisa ; Finkbeiner, Matthias (2018-07-02)

The needs of children and their vulnerability to diseases, violence and poverty are different from those of adults. The Sustainable Child Development Index (SCDI) was thus developed in previous work to evaluate the status of sustainable development for countries with a focus on children and triple-bottom-line thinking. This study proposes application options to put the SCDI into practice. The S...

Entwicklung eines Prototyps zur dynamischen Fließschemasimulation von Prozessen der Aufbereitung gemischter Siedlungsabfälle

Platzk, Stefan (2018)

Die vorliegende Arbeit befasst sich mit der Erschaffung und exemplarischen Anwendung eines Prototyps zur Modellierung und dynamischen Fließschemasimulation von Abfallbehandlungsverfahren. Zur Eingrenzung des Betrachtungsrahmens wird einführend der Wissensstand zum Stoffsystem „Gemischte Siedlungsabfälle“ zusammengetragen. Neben den jährlich in Deutschland anfallenden Mengen und erzielten Verwer...

An observational study of ballooning in large spiders: Nanoscale multifibers enable large spiders’ soaring flight

Cho, Moonsung ; Neubauer, Peter ; Fahrenson, Christoph ; Rechenberg, Ingo (2018-06-14)

The physical mechanism of aerial dispersal of spiders, “ballooning behavior,” is still unclear because of the lack of serious scientific observations and experiments. Therefore, as a first step in clarifying the phenomenon, we studied the ballooning behavior of relatively large spiders (heavier than 5 mg) in nature. Additional wind tunnel tests to identify ballooning silks were implemented in t...

Construction of an improved Aspergillus niger platform for enhanced glucoamylase secretion

Fiedler, Markus R. M. ; Barthel, Lars ; Kubisch, Christin ; Nai, Corrado ; Meyer, Vera (2018-06-16)

Background The lifestyle of filamentous fungi depends on the secretion of hydrolytic enzymes into the surrounding medium, which degrade polymeric substances into monomers that are then taken up to sustain metabolism. This feature has been exploited in biotechnology to establish platform strains with high secretory capacity including Aspergillus niger. The accepted paradigm is that proteins bec...

The PSS quality framework for solar home systems

Kebir, Noara Zohra ; Philipp, Daniel (2016-08)

In September 2015, the United Nations General Assembly has adopted the Sustainable Development Goals; they include SDG 7 targeting universal access to electricity by 2030. Reaching this goal implies huge investments in generation capacity, grid extension and densification. However, according to the International Energy Agency, 70% of the world's population currently excluded from electricity se...

Microscopic aspects of ageing in Al-Mg-Si alloys

Madanat, Mazen Adel (2018)

Al-Mg-Si alloys with a low solute content (0.4 %Mg, 0.4 %Si) and higher contents (Mg+Si=1.4 %, all in wt.%) were solutionized, quenched and then either artificially aged (AA) at 180 °C or naturally pre-aged (NPA) for 2 weeks at room temperature and then reverse aged (RA) at 250 °C. Subsequently, positron annihilation lifetime spectroscopy was applied with the objective of obtaining information ...