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Main Title: What makes Xanthomonas albilineans unique amongst xanthomonads?
Author(s): Pieretti, Isabelle
Pesic, Alexander
Petras, Daniel
Royer, Monique
Süßmuth, Roderich D.
Cociancich, Stéphane
Type: Article
Language Code: en
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Abstract: Xanthomonas albilineans causes leaf scald, a lethal disease of sugarcane. Compared to other species of Xanthomonas, X. albilineans exhibits distinctive pathogenic mechanisms, ecology and taxonomy. Its genome, which has experienced significant erosion, has unique genomic features. It lacks two loci required for pathogenicity in other plant pathogenic species of Xanthomonas: the xanthan gum biosynthesis and the Hrp-T3SS (hypersensitive response and pathogenicity-type three secretion system) gene clusters. Instead, X. albilineans harbors in its genome an SPI-1 (Salmonella pathogenicity island-1) T3SS gene cluster usually found in animal pathogens. X. albilineans produces a potent DNA gyrase inhibitor called albicidin, which blocks chloroplast differentiation, resulting in the characteristic white foliar stripe symptoms. The antibacterial activity of albicidin also confers on X. albilineans a competitive advantage against rival bacteria during sugarcane colonization. Recent chemical studies have uncovered the unique structure of albicidin and allowed us to partially elucidate its fascinating biosynthesis apparatus, which involves an enigmatic hybrid PKS/NRPS (polyketide synthase/non-ribosomal peptide synthetase) machinery.
Issue Date: 2015
Date Available: 24-Apr-2017
DDC Class: 572 Biochemie
Subject(s): Xanthomonas albilineans
leaf scald disease of sugarcane
genomic features
NRPS and PKS genes
Journal Title: Frontiers in plant science
Publisher: Frontiers Media
Publisher Place: Lausanne
Volume: 6
Issue: April 2015
Article Number: 289
Publisher DOI: 10.3389/fpls.2015.00289
Page Start: 1
Page End: 7
EISSN: 1664-462X
Appears in Collections:Inst. Chemie » Publications

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