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Main Title: Novel wet micro-contact deprinting method for patterning gold nanoparticles on PEG-hydrogels and thereby controlling cell adhesion
Author(s): Yesildag, Cigdem
Bartsch, Christoph
Vicente, Gonzalo de
Lensen, Marga C.
Type: Article
Language Code: en
Abstract: In the present work we introduce a novel method to create linear and rectangular micro-patterns of gold nanoparticles (Au NPs) on poly(ethylene glycol) (PEG) hydrogels. The strategy consists of removing Au NPs from defined regions of the silicon wafer by virtue of the swelling effect of the hydrogel. Using this method, which we denote as “Wet Micro-Contact Deprinting”, well-defined micro-patterns of Au NPs on silicon can be created. This resulting pattern is then transferred from the hard substrate to the soft surface of PEG-hydrogels. These unique micro- and nano-patterned hydrogels were cultured with mouse fibroblasts L929 cells. The cells selectively adhered on the Au NPs coated area and avoided the pure PEG material. These patterned, nanocomposite biointerfaces are not only useful for biological and biomedical applications, such as tissue engineering and diagnostics, but also, for biosensor applications taking advantage of surface plasmon resonance (SPR) or surface enhanced Raman scattering (SERS) effects, due to the optical properties of the Au NPs.
Issue Date: 2017
Date Available: 26-Jun-2017
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Subject(s): gold nanoparticles
poly(ethylene glycol) hydrogel
cell adhesion
Sponsor/Funder: DFG, TH 662/19-1, Open Access Publizieren 2017 - 2018 / Technische Universität Berlin
Journal Title: Polymers
Publisher: MDPI
Publisher Place: Basel
Volume: 9
Issue: 5
Article Number: 176
Publisher DOI: 10.3390/polym9050176
ISSN: 2073-4360
Appears in Collections:FG Nanostrukturierte Biomaterialien » Publications

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