FG Biologische Chemie

4 Items

Recent Submissions
Comprehensive snake venomics of the Okinawa Habu pit viper, Protobothrops flavoviridis, by complementary mass spectrometry-guided approaches

Damm, Maik ; Hempel, Benjamin-Florian ; Nalbantsoy, Ayse ; Süßmuth, Roderich D. (2018-07-29)

The Asian world is home to a multitude of venomous and dangerous snakes, which are used to induce various medical effects in the preparation of traditional snake tinctures and alcoholics, like the Japanese snake wine, named Habushu. The aim of this work was to perform the first quantitative proteomic analysis of the Protobothrops flavoviridis pit viper venom. Accordingly, the venom was analyzed...

Comparative venomics of the Vipera ammodytes transcaucasiana and Vipera ammodytes montandoni from Turkey provides insights into kinship

Hempel, Benjamin-Florian ; Damm, Maik ; Göçmen, Bayram ; Karis, Mert ; Oguz, Mehmet Anıl ; Nalbantsoy, Ayse ; Süßmuth, Roderich D. (2018)

The Nose-horned Viper (Vipera ammodytes) is one of the most widespread and venomous snakes in Europe, which causes high frequent snakebite accidents. The first comprehensive venom characterization of the regional endemic Transcaucasian Nose-horned Viper (Vipera ammodytes transcaucasiana) and the Transdanubian Sand Viper (Vipera ammodytes montandoni) is reported employing a combination of intact...

Synthese von fluoreszierenden 7-Azatryptophan-Derivaten und deren Einbau in Modellpeptide

Noichl, Benjamin Philipp (2017)

In nature, proteins evolve to ensure the survival of living organisms in their natural environments. To equip them with new features and functions, classical protein engineering, based on canonical twenty amino acids, could lead to the improvement of these proteins by mutagenesis. Proteins sequences containing exclusively naturally occurring amino acids (i.e. canonical 20) are often unsuitable ...

Biological effects of paenilamicin, a secondary metabolite antibiotic produced by the honey bee pathogenic bacterium Paenibacillus larvae

Garcia-Gonzalez, Eva ; Müller, Sebastian ; Hertlein, Gillian ; Heid, Nina ; Süßmuth, Roderich D. ; Genersch, Elke (2014)

Paenibacillus larvae is the etiological agent of American Foulbrood (AFB) a world-wide distributed devastating disease of the honey bee brood. Previous comparative genome analysis and more recently, the elucidation of the bacterial genome, provided evidence that this bacterium harbors putative functional nonribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs) and therefore, mig...