Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-6009
Main Title: NAD(H)-coupled hydrogen cycling - structure-function relationships of bidirectional [NiFe] hydrogenases
Author(s): Horch, Marius
Lauterbach, Lars
Lenz, Oliver
Hildebrandt, Peter
Zebger, Ingo
Type: Article
Language Code: en
Is Part Of: 10.14279/depositonce-4518
Abstract: Hydrogenases catalyze the activation or production of molecular hydrogen. Due to their potential importance for future biotechnological applications, these enzymes have been in the focus of intense research for the past decades. Bidirectional [NiFe] hydrogenases are of particular interest as they couple the reversible cleavage of hydrogen to the redox conversion of NAD(H). In this account, we review the current state of knowledge about mechanistic aspects and structural determinants of these complex multi-cofactor enzymes. Special emphasis is laid on the oxygen-tolerant NAD(H)-linked bidirectional [NiFe] hydrogenase from Ralstonia eutropha. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
URI: http://depositonce.tu-berlin.de/handle/11303/6501
http://dx.doi.org/10.14279/depositonce-6009
Issue Date: 2012
Date Available: 14-Jul-2017
DDC Class: 570 Biowissenschaften, Biologie ; 530 Physik ; 610 Medizin, Gesundheit
Subject(s): Biocatalysis
Hydrogenase
Spectroscopy
Oxygen tolerance
NADH regeneration
Biofuel
Creative Commons License: https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal Title: FEBS letters
Publisher: Elsevier
Publisher Place: Amsterdam [u.a.]
Volume: 586
Issue: 5
Publisher DOI: 10.1016/j.febslet.2011.10.010
Page Start: 545
Page End: 556
EISSN: 1873-3468
ISSN: 0014-5793
Appears in Collections:Technische Universität Berlin » Fakultäten & Zentralinstitute » Fakultät 2 Mathematik und Naturwissenschaften » Institut für Chemie » Fachgebiet Physikalische Chemie / Biophysikalische Chemie » Publications

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