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Main Title: Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products
Author(s): Al Toma, Rashed S.
Brieke, Clara
Cryle, Max J.
Süßmuth, Roderich D.
Type: Article
Language Code: en
Abstract: Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and phenylglycine (Phg) in recent years. The significance and importance of this type of unusual non-proteinogenic aromatic amino acids also for medicinal chemistry has drawn the attention of many research groups and pharmaceutical companies. Herein structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenylglycines are discussed.
Issue Date: 2015
Date Available: 25-Oct-2017
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, EXC 314, Unifying Concepts in Catalysis
EC/FP7/613877/EU/Rewiring the Streptomyces cell factory for cost-effective production of biomolecules/STREPSYNTH
DFG, CR 392/1-1, Structural and mechanistic investigation of the Cytochrome P450 enzymes in vancomycin biosynthesis: potential biocatalysts for the development of new antibiotics
Journal Title: Natural product reports
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 32
Issue: 8
Publisher DOI: 10.1039/c5np00025d
Page Start: 1207
Page End: 1235
EISSN: 1460-4752
ISSN: 0265-0568
Appears in Collections:FG Organische Chemie » Publications

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