Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-6283
|Main Title:||Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products|
|Author(s):||Al Toma, Rashed S.|
Cryle, Max J.
Süßmuth, Roderich D.
|Abstract:||Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and phenylglycine (Phg) in recent years. The significance and importance of this type of unusual non-proteinogenic aromatic amino acids also for medicinal chemistry has drawn the attention of many research groups and pharmaceutical companies. Herein structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenylglycines are discussed.|
|DDC Class:||540 Chemie und zugeordnete Wissenschaften|
|Sponsor/Funder:||DFG, EXC 314, Unifying Concepts in Catalysis|
EC/FP7/613877/EU/Rewiring the Streptomyces cell factory for cost-effective production of biomolecules/STREPSYNTH
DFG, CR 392/1-1, Structural and mechanistic investigation of the Cytochrome P450 enzymes in vancomycin biosynthesis: potential biocatalysts for the development of new antibiotics
|Journal Title:||Natural product reports|
|Publisher:||Royal Society of Chemistry|
|Appears in Collections:||FG Organische Chemie » Publications|
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