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Main Title: Involvement of secondary metabolites in the pathogenesis of the American foulbrood of honey bees caused by Paenibacillus larvae
Author(s): Müller, Sebastian
García-Gonzalez, Eva
Genersch, Elke
Süßmuth, Roderich D.
Type: Article
Language Code: en
Abstract: Covering: 2011 to end of 2014 The Gram-positive, spore-forming bacterium Paenibacillus larvae (P. larvae) is the causative agent of the epizootic American Foulbrood (AFB), a fatal brood disease of the western honey bee (Apis mellifera). AFB is one of the most destructive honey bee diseases since it is not only lethal for infected larvae but also for the diseased colonies. Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem. Knowledge about virulence mechanisms and the underlying molecular mechanisms remain largely elusive. Recent genome sequencing of P. larvae revealed its potential to produce unknown secondary metabolites, like nonribosomal peptides and peptide-polyketide hybrids. This article highlights recent findings on secondary metabolites synthesized by P. larvae and discusses their role in virulence and pathogenicity towards the bee larvae.
Issue Date: 2015
Date Available: 25-Oct-2017
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Journal Title: Natural product reports
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 32
Issue: 6
Publisher DOI: 10.1039/c4np00158c
Page Start: 765
Page End: 778
EISSN: 1460-4752
ISSN: 0265-0568
Appears in Collections:FG Organische Chemie » Publications

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