FG Lebensmittelchemie und Toxikologie

10 Items

Recent Submissions
Toxicity Assay for Citrinin, Zearalenone and Zearalenone-14-Sulfate Using the Nematode Caenorhabditis elegans as Model Organism

Keller, Julia ; Borzekowski, Antje ; Haase, Hajo ; Menzel, Ralph ; Rueß, Liliane ; Koch, Matthias (2018-07-09)

To keep pace with the rising number of detected mycotoxins, there is a growing need for fast and reliable toxicity tests to assess potential threats to food safety. Toxicity tests with the bacterial-feeding nematode Caenorhabditis elegans as the model organism are well established. In this study the C. elegans wildtype strain N2 (var. Bristol) was used to investigate the toxic effects of the fo...

Zinc and Sepsis

Alker, Wiebke ; Haase, Hajo (2018-07-27)

Sepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and ...

Influence of Media Heat Sterilization Process on Growth Performance of Representative Strains of the Genus Lactobacillus

Senz, Martin ; Keil, Claudia ; Schmacht, Maximilian ; Palinski, Sophie ; Cämmerer, Bettina ; Hageböck, Martin (2019-02-15)

Lactic acid bacteria (LAB) are widely applied microorganisms in food, feed, and beverage applications, where they can provide essential functionality for product modification, increase product shelf life, or act as beneficial organisms after consumption. Among these, strains of the genus Lactobacillus are often used as starters, probiotics, or biopreservatives. For all these types of bacterial ...

In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins

Maares, Maria Henrietta ; Keil, Claudia ; Koza, Jenny ; Straubing, Sophia ; Schwerdtle, Tanja ; Haase, Hajo (2018-09-07)

The investigation of luminal factors influencing zinc availability and accessibility in the intestine is of great interest when analyzing parameters regulating intestinal zinc resorption. Of note, intestinal mucins were suggested to play a beneficial role in the luminal availability of zinc. Their exact zinc binding properties, however, remain unknown and the impact of these glycoproteins on hu...

Synthesis and Structural Identification of a Biaryl Ether-Linked Zearalenone Dimer

Keller, Julia ; Hantschke, Luisa ; Haase, Hajo ; Koch, Matthias (2018-10-12)

A new dimer of the food-relevant mycotoxin zearalenone was isolated after electrochemical and chemical oxidation. The structure was determined as a 16-O-15′-biaryl ether-linked dimer based on spectroscopic analyses (1H- and 13C-NMR, COSY, HMBC, and HSQCAD) and high-resolution mass spectrometry analysis (Q-TOF).

Investigations on zinc resorption using in vitro intestinal models

Maares, Maria Henrietta (2019)

The essential trace element zinc is mainly resorbed in the small intestine, where the luminal available cation is absorbed by enterocytes of the intestinal epithelium and transported into the blood circulation. In the past four decades substantial progress in the overall understanding of zinc homeostasis was made by elucidating that the intestinal zinc resorption regulates the systemic homeosta...

Effect of Different Drying Methods on Nutrient Quality of the Yellow Mealworm (Tenebrio molitor L.)

Kröncke, Nina ; Grebenteuch, Sandra ; Keil, Claudia ; Demtröder, Sebastian ; Kroh, Lothar ; Thünemann, Andreas F. ; Benning, Rainer ; Haase, Hajo (2019-03-27)

Yellow mealworm (Tenebrio molitor L.) represents a sustainable source of proteins and fatty acids for feed and food. Industrial production of mealworms necessitates optimized processing techniques, where drying as the first postharvest procedure is of utmost importance for the quality of the final product. This study examines the nutritional quality of mealworm larvae processed by rack oven dry...

Formation of a carcinogenic aromatic amine from an azo dye by human skin bacteria in vitro

Platzek, T. ; Lang, C. ; Grohmann, G. ; Gi, U.-S. ; Baltes, W. (1999)

Azo dyes represent the major class of dyestuffs. They are metabolised to the corresponding amines by liver enzymes and the intestinal microflora following incorporation by both experimental animals and humans. For safety evaluation of the dermal exposure of consumers to azo dyes from wearing coloured textiles, a possible cleavage of azo dyes by the skin microflora should be considered since, in...

Comparison of methods for determining the effectiveness of antibacterial functionalized textiles

Haase, Hajo ; Jordan, Lisa ; Keitel, Laura ; Keil, Claudia ; Mahltig, Boris (2017)

Antimicrobial functionalization of textiles is important for various applications, such as protection of textile materials from decomposition, generation of more effective wound dressings, and the prevention of infections or malodors resulting from bacterial growth. In order to test the efficacy of new products, their antibacterial activity needs to be evaluated. At present, several different p...

In silico Toxizitätsvorhersage der hitzebedingten Lebensmittelkontaminanten 3-MCPD, 2-MCPD und 2-MCPD-Dipalmitat und anschließende vergleichende proteomische Analyse substanzinduzierter molekularer Veränderungen in Leber, Niere, Hoden und Herz der Ratte

Frenzel, Falko (2017-11)

Die Entdeckung einer Vielzahl an Produkten der Maillard-Reaktion und Lipidoxidation in einem breiten Spektrum an zubereiteten Lebensmitteln wie etwa Grillgut, Kaffee, Pflanzenölen und erhitztem Getreide setzte die behördlichen Verbraucherschützer unter Druck. In Ermangelung hinreichender Daten zu toxikologischen Eigenschaften ist eine adäquate Risikobewertung für viele hitzebedingte Lebensmitte...