FG Lebensmittelchemie und Toxikologie

25 Items

Recent Submissions
Nutritive Manganese and Zinc Overdosing in Aging C. elegans Result in a Metallothionein‐Mediated Alteration in Metal Homeostasis

Baesler, Jessica ; Michaelis, Vivien ; Stiboller, Michael ; Haase, Hajo ; Aschner, Michael ; Schwerdtle, Tanja ; Sturzenbaum, Stephen R. ; Bornhorst, Julia (2021-03-09)

Scope Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study ...

A Nanotubular Metal–Organic Framework with a Narrow Bandgap from Extended Conjugation**

Ayhan, M. Menaf ; Bayraktar, Ceyda ; Yu, Kai Bin ; Hanna, Gabriel ; Yazaydin, A. Ozgur ; Zorlu, Yunus ; Yücesan, Gündoğ (2020-10-15)

A one‐dimensional nanotubular metal–organic framework (MOF) [Ni(Cu‐H4TPPA)]⋅2 (CH3)2NH2+ (H8TPPA=5,10,15,20‐tetrakis[p‐phenylphosphonic acid] porphyrin) constructed by using the arylphosphonic acid H8TPPA is reported. The structure of this MOF, known as GTUB‐4, was solved by using single‐crystal X‐ray diffraction and its geometric accessible surface area was calculated to be 1102 m2 g−1, making...

Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae

Keil, Claudia ; Maares, Maria ; Kröncke, Nina ; Benning, Rainer ; Haase, Hajo (2020-11-18)

The industrial production of Tenebrio molitor L. requires optimized rearing and processing conditions to generate insect biomass with high nutritional value in large quantities. One of the problems arising from processing is a tremendous loss in mineral accessibility, affecting, amongst others, the essential trace element Zn. As a feasible strategy this study investigates Zn-enrichment of mealw...

Comparison of free zinc levels determined by fluorescent probes in THP1 cells using microplate reader and flow cytometer

Alker, Wiebke ; Haase, Hajo (2020-08-31)

Free zinc is involved in signal transduction within mammalian cells, acting as a second messenger. Gold standard for its analysis is currently the use of metal-responsive fluorescent probes. The present study elucidates the impact of instrumentation used for measuring the resulting fluorescence. The free zinc concentration of THP-1 cells loaded with the fluorescent probes Zinpyr-1 (ZP1) or Fluo...

Time- and Zinc-Related Changes in Biomechanical Properties of Human Colorectal Cancer Cells Examined by Atomic Force Microscopy

Maares, Maria ; Keil, Claudia ; Löher, Leif ; Weber, Andreas ; Andorfer-Sarr, Amsatou ; Haase, Hajo ; Iturri, Jagoba ; Toca-Herrera, José L. (2020-12-14)

Monitoring biomechanics of cells or tissue biopsies employing atomic force microscopy (AFM) offers great potential to identify diagnostic biomarkers for diseases, such as colorectal cancer (CRC). Data on the mechanical properties of CRC cells, however, are still scarce. There is strong evidence that the individual zinc status is related to CRC risk. Thus, this study investigates the impact of d...

Ca-Zn-Ag Alginate Aerogels for Wound Healing Applications: Swelling Behavior in Simulated Human Body Fluids and Effect on Macrophages

Keil, Claudia ; Hübner, Christopher ; Richter, Constanze ; Lier, Sandy ; Barthel, Lars ; Meyer, Vera ; Subrahmanyam, Raman ; Gurikov, Pavel ; Smirnova, Irina ; Haase, Hajo (2020-11-18)

Chronic non-healing wounds represent a substantial economic burden to healthcare systems and cause a considerable reduction in quality of life for those affected. Approximately 0.5–2% of the population in developed countries are projected to experience a chronic wound in their lifetime, necessitating further developments in the area of wound care materials. The use of aerogels for wound healing...

A 3D Cu‐Naphthalene‐Phosphonate Metal–Organic Framework with Ultra‐High Electrical Conductivity

Peeples, Craig A. ; Kober, Delf ; Schmitt, Franz‐Josef ; Tholen, Patrik ; Siemensmeyer, Konrad ; Halldorson, Quinn ; Çoşut, Bünyemin ; Gurlo, Aleksander ; Yazaydin, Ahmet Ozgur ; Hanna, Gabriel ; Yücesan, Gündoğ (2020-10-02)

A conductive phosphonate metal–organic framework (MOF), [{Cu(H2O)}(2,6‐NDPA)0.5] (NDPA = naphthalenediphosphonic acid), which contains a 2D inorganic building unit (IBU) comprised of a continuous edge‐sharing sheet of copper phosphonate polyhedra is reported. The 2D IBUs are connected to each other via polyaromatic 2,6‐NDPA's, forming a 3D pillared‐layered MOF structure. This MOF, known as TUB4...

Semiconductive microporous hydrogen-bonded organophosphonic acid frameworks

Tholen, Patrik ; Peeples, Craig A. ; Schaper, Raoul ; Bayraktar, Ceyda ; Erkal, Turan Selman ; Ayhan, Mehmet Menaf ; Çoşut, Bünyemin ; Beckmann, Jens ; Yazaydin, A. Ozgur ; Wark, Michael ; Hanna, Gabriel ; Zorlu, Yunus ; Yücesan, Gündoğ (2020-06-23)

Herein, we report a semiconductive, proton-conductive, microporous hydrogen-bonded organic framework (HOF) derived from phenylphosphonic acid and 5,10,15,20‐tetrakis[p‐phenylphosphonic acid] porphyrin (GTUB5). The structure of GTUB5 was characterized using single crystal X-ray diffraction. A narrow band gap of 1.56 eV was extracted from a UV-Vis spectrum of pure GTUB5 crystals, in excellent agr...

Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study

Hoeger, Janine ; Simon, Tim-Philipp ; Beeker, Thorben ; Marx, Gernot ; Haase, Hajo ; Schürholz, Tobias (2017-05-04)

Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution and prognostic value of serum zinc levels in sepsis patients. We performed a prospective observational single-center study set in a tertiary car...

Probing Isoreticular Expansions in Phosphonate MOFs and their Applications

Tholen, Patrik ; Zorlu, Yunus ; Beckmann, Jens ; Yücesan, Gündoğ (2020-03-26)

This review is divided into three different parts. In the introduction, the current applications of metal‐organic frameworks (MOFs) are shown. Furthermore, the overall stability, a comparison of phosphonate MOFs with carboxylate MOFs, the structural richness of phosphonate MOFs with the challenge in synthesis and different linker geometries is discussed. In the second part, several phosphonate ...

Fluorescent Arylphosphonic Acids: Synergic Interactions between Bone and the Fluorescent Core

Zorlu, Yunus ; Brown, Connor ; Keil, Claudia ; Ayhan, M. Menaf ; Haase, Hajo ; Thompson, Richard B. ; Lengyel, Imre ; Yücesan, Gündoğ (2020-07-28)

Herein, we report the third generation of fluorescent probes (arylphosphonic acids) to target calcifications, particularly hydroxyapatite (HAP). In this study, we use highly conjugated porphyrin‐based arylphosphonic acids and their diesters, namely 5,10,15,20‐tetrakis[m‐(diethoxyphosphoryl)phenyl]porphyrin (m‐H8TPPA‐OEt8) and 5,10,15,20‐tetrakis [m‐phenylphosphonic acid]porphyrin (m‐H8TPPA), in...

Impact of Media Heat Treatment on Cell Morphology and Stability of L. acidophilus, L. johnsonii and L. delbrueckii subsp. delbrueckii during Fermentation and Processing

Ludszuweit, Marie ; Schmacht, Maximilian ; Keil, Claudia ; Haase, Hajo ; Senz, Martin (2020-09-25)

Manufacturers of starter cultures and probiotics aim to provide preparations with the highest possible amount of living cells and assurance of long-term storage stability. Thereby the industrial economy and thus an efficient outcome of the processes is of utmost importance. Earlier research has shown that the sterilization procedure of the microbial culture medium tremendously impacts growth pe...

Phosphonate Metal–Organic Frameworks: A Novel Family of Semiconductors

Siemensmeyer, Konrad ; Peeples, Craig A. ; Tholen, Patrik ; Schmitt, Franz‐Josef ; Çoşut, Bünyemin ; Hanna, Gabriel ; Yücesan, Gündoğ (2020-05-06)

Herein, the first semiconducting and magnetic phosphonate metal–organic framework (MOF), TUB75, is reported, which contains a 1D inorganic building unit composed of a zigzag chain of corner‐sharing copper dimers. The solid‐state UV–vis spectrum of TUB75 reveals the existence of a narrow bandgap of 1.4 eV, which agrees well with the density functional theory (DFT)‐calculated bandgap of 1.77 eV. ...

A cobalt arylphosphonate MOF – superior stability, sorption and magnetism

Zorlu, Yunus ; Erbahar, Doğan ; Çetinkaya, Ahmet ; Bulut, Aysun ; Erkal, Turan S. ; Yazaydin, A. Ozgur ; Beckmann, Jens ; Yücesan, Gündoğ (2019-01-25)

We report a novel metal-organic framework (MOF) based on a cobalt arylphosphonate, namely, [Co2(H4-MTPPA)]·3NMP·H2O (1·3NMP·H2O), which was prepared solvothermically from the tetrahedral linker tetraphenylmethane tetrakis-4-phosphonic acid (H8-MTPPA) and CoSO4·7H2O in N-methyl-2-pyrrolidone (NMP). Compound 1 has the highest porosity (BET surface area of 1034 m2 g−1) ever reported for a MOF base...

A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models

Maares, Maria ; Haase, Hajo (2020-03-13)

Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution. In particular, current knowledge on human intestinal zinc absorption and the influence of diet-derived factors on bioaccessibility and bioavailability as well as intrinsic lumi...

Toxicity Assay for Citrinin, Zearalenone and Zearalenone-14-Sulfate Using the Nematode Caenorhabditis elegans as Model Organism

Keller, Julia ; Borzekowski, Antje ; Haase, Hajo ; Menzel, Ralph ; Rueß, Liliane ; Koch, Matthias (2018-07-09)

To keep pace with the rising number of detected mycotoxins, there is a growing need for fast and reliable toxicity tests to assess potential threats to food safety. Toxicity tests with the bacterial-feeding nematode Caenorhabditis elegans as the model organism are well established. In this study the C. elegans wildtype strain N2 (var. Bristol) was used to investigate the toxic effects of the fo...

Zinc and Sepsis

Alker, Wiebke ; Haase, Hajo (2018-07-27)

Sepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and ...

Influence of Media Heat Sterilization Process on Growth Performance of Representative Strains of the Genus Lactobacillus

Senz, Martin ; Keil, Claudia ; Schmacht, Maximilian ; Palinski, Sophie ; Cämmerer, Bettina ; Hageböck, Martin (2019-02-15)

Lactic acid bacteria (LAB) are widely applied microorganisms in food, feed, and beverage applications, where they can provide essential functionality for product modification, increase product shelf life, or act as beneficial organisms after consumption. Among these, strains of the genus Lactobacillus are often used as starters, probiotics, or biopreservatives. For all these types of bacterial ...

In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins

Maares, Maria Henrietta ; Keil, Claudia ; Koza, Jenny ; Straubing, Sophia ; Schwerdtle, Tanja ; Haase, Hajo (2018-09-07)

The investigation of luminal factors influencing zinc availability and accessibility in the intestine is of great interest when analyzing parameters regulating intestinal zinc resorption. Of note, intestinal mucins were suggested to play a beneficial role in the luminal availability of zinc. Their exact zinc binding properties, however, remain unknown and the impact of these glycoproteins on hu...

Synthesis and Structural Identification of a Biaryl Ether-Linked Zearalenone Dimer

Keller, Julia ; Hantschke, Luisa ; Haase, Hajo ; Koch, Matthias (2018-10-12)

A new dimer of the food-relevant mycotoxin zearalenone was isolated after electrochemical and chemical oxidation. The structure was determined as a 16-O-15′-biaryl ether-linked dimer based on spectroscopic analyses (1H- and 13C-NMR, COSY, HMBC, and HSQCAD) and high-resolution mass spectrometry analysis (Q-TOF).