FG Angewandte Biochemie

8 Items

Recent Submissions
Verbesserung des CVB3-Maus-Myokarditismodells durch die Entwicklung pankreasattenuierter Coxsackieviren

Pryshliak, Markian (2019)

Das Coxsackievirus B3 (CVB3)-Maus-Myokarditismodell wird standardmäßig zur Untersuchung der Virus-induzierten Myokarditis verwendet. Entgegen der CVB3-Infektion im Menschen stellt im murinen Organismus nicht das Herz, sondern das Pankreas das für die CVB3-Infektion suszeptibelste Organ dar. Verschiedene klinische Symptome, wie der starke Gewichtsverlust, das schmerzhafte Hochziehen des Bauches ...

Impact of TiO2 nanoparticles on the aquatic environment: Investigation of cyanobacterial toxin adsorption and oxidative stress mediated nanotoxicity towards the submerged aquatic macrophyte Hydrilla verticillata

Spengler, Annette (2019)

Manufactured TiO2-nanoparticles (TiO2-NPs) are the most commonly employed metal oxide-based NPs. Due to the greater surface area per unit volume compared with their respective microscale counterparts, TiO2-NPs might exhibit physicochemical properties which affect the toxicity potential of the normally inert material. Taking into account the increasing production volumes of TiO2-NPs, they will i...

Phthalocyanine-fullerene dyads and DNA interstrand cross-linking on surface

Véliz Montes, Cinthya Yamila (2018)

Nanotechnology deals with structures and components of nanoscale size in order to create new properties or to improve significantly their physical, chemical and biological properties, processes and phenomena. Many efforts of molecular nanotechnology are directed to design artificial nanostructures on surfaces due to their potential applications in nanodevices and biosensors. This thesis include...

Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies

Hiller, Thomas ; Berg, Johanna ; Elomaa, Laura ; Röhrs, Viola ; Ullah, Imran ; Schaar, Katrin ; Dietrich, Ann-Christin ; Al-Zeer, Munir A. ; Kurtz, Andreas ; Hocke, Andreas C. ; Hippenstiel, Stefan ; Fechner, Henry ; Weinhart, Marie ; Kurreck, Jens (2018-10-12)

Bioprinting is a novel technology that may help to overcome limitations associated with two-dimensional (2D) cell cultures and animal experiments, as it allows the production of three-dimensional (3D) tissue models composed of human cells. The present study describes the optimization of a bioink composed of alginate, gelatin and human extracellular matrix (hECM) to print human HepaRG liver cell...

Analysis of metabolic pathways controlling cAMP-regulated aquaporin-2 trafficking in renal principal cells

Schulz, Maike (2018)

One of the main effectors of the second messenger cyclic adenosine monophosphate (cAMP) is the ubiquitously expressed serine/threonine protein kinase, cAMP-dependent protein kinase (PKA). Binding of cAMP to the regulatory subunits of PKA results in a conformational change and the release of the catalytic subunits to phosphorylate nearby targets. To ensure spatially and temporally controlled pho...

Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus

Berg, Johanna ; Hiller, Thomas ; Kissner, Maya S. ; Qazi, Taimoor H. ; Duda, Georg N. ; Hocke, Andreas C. ; Hippenstiel, Stefan ; Elomaa, Laura ; Weinhart, Marie ; Fahrenson, Christoph ; Kurreck, Jens (2018-09-17)

Bioprinting is a new technology, which arranges cells with high spatial resolution, but its potential to create models for viral infection studies has not yet been fully realized. The present study describes the optimization of a bioink composition for extrusion printing. The bioinks were biophysically characterized by rheological and electron micrographic measurements. Hydrogels consisting of ...

Development of recombinant oncolytic Coxsackievirus B3 for treatment of colorectal carcinoma

Hazini, Ahmet (2018)

Colorectal cancer is one of the most death related cancer type in worldwide. Conventional cancer therapeutics show curable effect only in the patients at early stage of the disease. In case of the diagnosis at late stages, the survival rate decreases dramatically up to 10%. Therefore, novel cancer therapeutics are urgently needed. Oncolytic virotherapy is a new treatment approach which exploits...

Hepatitis E virus superinfection and clinical progression in hepatitis B patients

Hoan, Nghiem Xuan ; Tong, Hoang Van ; Hecht, Nicole ; Sy, Bui Tien ; Marcinek, Patrick ; Meyer, Christian G. ; Song, Le Huu ; Toan, Nguyen Linh ; Kurreck, Jens ; Kremsner, Peter G. ; Bock, C-Thomas ; Velavan, Thirumalaisamy P. (2015)

Hepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-r...