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Main Title: Burst-dependent bidirectional plasticity in the cerebellum Is driven by presynaptic NMDA receptors
Author(s): Bouvier, Guy
Higgins, David
Spolidoro, Maria
Carrel, Damien
Mathieu, Benjamin
Léna, Clément
Dieudonné, Stéphane
Barbour, Boris
Brunel, Nicolas
Casado, Mariano
Type: Article
Language Code: en
Abstract: Numerous studies have shown that cerebellar function is related to the plasticity at the synapses between parallel fibers and Purkinje cells. How specific input patterns determine plasticity outcomes, as well as the biophysics underlying plasticity of these synapses, remain unclear. Here, we characterize the patterns of activity that lead to postsynaptically expressed LTP using both in vivo and in vitro experiments. Similar to the requirements of LTD, we find that high-frequency bursts are necessary to trigger LTP and that this burst-dependent plasticity depends on presynaptic NMDA receptors and nitric oxide (NO) signaling. We provide direct evidence for calcium entry through presynaptic NMDA receptors in a subpopulation of parallel fiber varicosities. Finally, we develop and experimentally verify a mechanistic plasticity model based on NO and calcium signaling. The model reproduces plasticity outcomes from data and predicts the effect of arbitrary patterns of synaptic inputs on Purkinje cells, thereby providing a unified description of plasticity.
Issue Date: 24-Mar-2016
Date Available: 1-Jun-2018
DDC Class: 570 Biowissenschaften; Biologie
610 Medizin und Gesundheit
Subject(s): cerebellum
parallel fibers
Purkinje cells
NMDA receptors
nitric oxide
Sponsor/Funder: EC/FP7/238686/EU/Timing and plasticity in the olivo-cerebellar system/CEREBNET
Journal Title: Cell Reports
Publisher: Elsevier
Publisher Place: New York, NY
Volume: 15
Issue: 1
Publisher DOI: 10.1016/j.celrep.2016.03.004
Page Start: 104
Page End: 116
ISSN: 2211-1247
Appears in Collections:FG Modellierung kognitiver Prozesse » Publications

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