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Main Title: Facile Control over the Supramolecular Ordering of Selfassembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride
Author(s): Li, Rui
Boyd-Moss, Mitchell
Long, Benjamin
Martel, Anne
Parnell, Andrew
Dennison, Andrew J. C.
Barrow, Colin J.
Nisbet, David R.
Williams, Richard J.
Type: Article
Language Code: en
Abstract: Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.
Issue Date: 6-Jul-2017
Date Available: 14-Jun-2018
DDC Class: 500 Naturwissenschaften und Mathematik
600 Technik, Technologie
Subject(s): biomaterial engineering
control over macromolecular ordering
self-assembly of minimalist peptides
Fmoc-FRGDF peptide
Journal Title: Scientific Reports
Publisher: Macmillan Publishers Limited, part of Springer Nature
Publisher Place: [London]
Volume: 7
Article Number: 4797
Publisher DOI: 10.1038/s41598-017-04643-3
Page Start: 1
Page End: 8
ISSN: 2045-2322
Appears in Collections:FG Physikalische Chemie / Molekulare Materialwissenschaften » Publications

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