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Main Title: Micro-Patterning of PEG-Based Hydrogels With Gold Nanoparticles Using a Reactive Micro-Contact-Printing Approach
Author(s): Yesildag, Cigdem
Ouyang, Zhaofei
Zhang, Zhenfang
Lensen, Marga C.
Type: Article
Language Code: en
Abstract: In this work a novel, relatively simple, and fast method for patterning of gold nanoparticles (Au NPs) on poly(ethylene glycol) (PEG)-based hydrogels is presented. In the hereby exploited reactive micro-contact printing (reactive-μ-CP) process, the surface of a micro-relief patterned PDMS-stamp is first functionalized with an amino-silane self-assembled monolayer (SAM), which is then inked with Au NPs. The stamp is subsequently brought into conformal contact with thiol-functionalized PEG-based hydrogel films. Due to the strong gold-thiol interactions the Au NPs are adequately and easily transferred onto the surfaces of these soft, multifunctional PEG hydrogels. In this way, defined μ-patterns of Au NPs on PEG hydrogels are achieved. These Au NPs patterns allow specific biomolecular interactions on PEG surfaces, and cell adhesion has been studied. Cells were found to effectively adhere only on Au NPs micro-patterns and to avoid the anti-adhesive PEG background. Besides the cell adhesion studies, these Au NPs μ-patterns can be potentially applied as biosensors in plasmon-based spectroscopic devices or in medicine, e.g., for drug delivery systems or photothermal therapies.
Issue Date: 17-Jan-2019
Date Available: 20-Feb-2019
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Subject(s): PEG hydrogel
Au NPs
cell adhension
Sponsor/Funder: DFG, 414044773, Open Access Publizieren 2019 - 2020 / Technische Universität Berlin
Journal Title: Frontiers in Chemistry
Publisher: Frontiers Media
Publisher Place: Lausanne
Volume: 6
Article Number: 667
Publisher DOI: 10.3389/fchem.2018.00667
EISSN: 2296-2646
Appears in Collections:FG Nanostrukturierte Biomaterialien » Publications

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