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Main Title: Synthesis of N-heterocycles from diamines via H2-driven NADPH recycling in the presence of O2
Author(s): Al-Shameri, Ammar
Borlinghaus, Niels
Weinmann, Leonie
Scheller, Philipp N.
Nestl, Bettina M.
Lauterbach, Lars
Type: Article
Language Code: en
Abstract: Herein, we report an enzymatic cascade involving an oxidase, an imine reductase and a hydrogenase for the H2-driven synthesis of N-heterocycles. Variants of putrescine oxidase from Rhodococcus erythropolis with improved activity were identified. Substituted pyrrolidines and piperidines were obtained with up to 97% product formation in a one-pot reaction directly from the corresponding diamine substrates. The formation of up to 93% ee gave insights into the specificity and selectivity of the putrescine oxidase.
Issue Date: 23-Jan-2019
Date Available: 30-Apr-2019
DDC Class: 540 Chemie und zugeordnete Wissenschaften
Sponsor/Funder: DFG, 53182490, EXC 314: Unifying Concepts in Catalysis
DFG, 284111627, H2-basierende Kaskaden für die Biosynthese von N-Heterocyclen
TU Berlin, Open-Access-Mittel - 2019
Journal Title: Green Chemistry
Publisher: Royal Society of Chemistry
Publisher Place: Cambridge
Volume: 21
Issue: 6
Publisher DOI: 10.1039/C8GC03798A
Page Start: 1396
Page End: 1400
EISSN: 1463-9270
ISSN: 1463-9262
Appears in Collections:Inst. Chemie » Publications

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