Please use this identifier to cite or link to this item:
http://dx.doi.org/10.14279/depositonce-8881
Main Title: | Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics |
Author(s): | Bogomolov, Andrey Zabarylo, Urszula Kirsanov, Dmitry Belikova, Valeria Ageev, Vladimir Usenov, Iskander Galyanin, Vladislav Minet, Olaf Sakharova, Tatiana Danielyan, Georgy Feliksberger, Elena Artyushenko, Viacheslav |
Type: | Article |
Language Code: | en |
Abstract: | Optical spectroscopy is increasingly used for cancer diagnostics. Tumor detection feasibility in human kidney samples using mid- and near-infrared (NIR) spectroscopy, fluorescence spectroscopy, and Raman spectroscopy has been reported (Artyushenko et al., Spectral fiber sensors for cancer diagnostics in vitro. In Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 21–25 June 2015). In the present work, a simplification of the NIR spectroscopic analysis for cancer diagnostics was studied. The conventional high-resolution NIR spectroscopic method of kidney tumor diagnostics was replaced by a compact optical sensing device constructively represented by a set of four light-emitting diodes (LEDs) at selected wavelengths and one detecting photodiode. Two sensor prototypes were tested using 14 in vitro clinical samples of 7 different patients. Statistical data evaluation using principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) confirmed the general applicability of the LED-based sensing approach to kidney tumor detection. An additional validation of the results was performed by means of sample permutation. |
URI: | https://depositonce.tu-berlin.de/handle/11303/9869 http://dx.doi.org/10.14279/depositonce-8881 |
Issue Date: | 19-Aug-2017 |
Date Available: | 23-Aug-2019 |
DDC Class: | 610 Medizin und Gesundheit 530 Physik |
Subject(s): | tumor detection kidney fiber spectroscopy optical sensor near infrared LED |
License: | https://creativecommons.org/licenses/by/4.0/ |
Journal Title: | Sensors |
Publisher: | MDPI |
Publisher Place: | Basel |
Volume: | 17 |
Issue: | 8 |
Article Number: | 1914 |
Publisher DOI: | 10.3390/s17081914 |
EISSN: | 1424-8220 |
Appears in Collections: | FG Nichtlineare Optik » Publications |
Files in This Item:
File | Description | Size | Format | |
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sensors-17-01914.pdf | 4.12 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License