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Main Title: Application of Continuous Culture Methods to Recombinant Protein Production in Microorganisms
Author(s): Peebo, Karl
Neubauer, Peter
Type: Article
Language Code: en
Abstract: Depending on the environmental conditions, cells adapt their metabolism and specific growth rate. Rearrangements occur on many different levels such as macromolecular composition, gene and protein expression, morphology and metabolic flux patterns. As the interplay of these processes also determines the output of a recombinant protein producing system, having control over specific growth rate of the culture is advantageous. Continuous culture methods were developed to grow cells in a constant environment and have been used for decades to study basic microbial physiology in a controlled and reproducible manner. Our review summarizes the uses of continuous cultures in cell physiology studies and process development, with a focus on recombinant protein-producing microorganisms.
Issue Date: 21-Jun-2018
Date Available: 23-Aug-2019
DDC Class: 570 Biowissenschaften; Biologie
Subject(s): continuous cultures
continuous manufacturing
recombinant protein production
steady state
specific growth rate
Journal Title: Microorganisms
Publisher: MDPI
Publisher Place: Basel
Volume: 6
Issue: 3
Article Number: 56
Publisher DOI: 10.3390/microorganisms6030056
EISSN: 2076-2607
Appears in Collections:FG Bioverfahrenstechnik » Publications

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