Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-8915
Main Title: Safety Aspects, Tolerability and Modeling of Retinofugal Alternating Current Stimulation
Author(s): Haberbosch, Linus
Datta, Abhishek
Thomas, Chris
Jooß, Andreas
Köhn, Arvid
Rönnefarth, Maria
Scholz, Michael
Brandt, Stephan A.
Schmidt, Sein
Type: Article
Language Code: en
Abstract: Background While alternating current stimulation (ACS) is gaining relevance as a tool in research and approaching clinical applications, its mechanisms of action remain unclear. A review by Schutter and colleagues argues for a retinal origin of transcranial ACS’ neuromodulatory effects. Interestingly, there is an alternative application form of ACS specifically targeting α-oscillations in the visual cortex via periorbital electrodes (retinofugal alternating current stimulation, rACS). To further compare these two methods and investigate retinal effects of ACS, we first aim to establish the safety and tolerability of rACS. ObjectiveThe goal of our research was to evaluate the safety of rACS via finite-element modeling, theoretical safety limits and subjective report. Methods20 healthy subjects were stimulated with rACS as well as photic stimulation and reported adverse events following stimulation. We analyzed stimulation parameters at electrode level as well as distributed metric estimates from an ultra-high spatial resolution magnetic resonance imaging (MRI)-derived finite element human head model and compared them to existing safety limits. ResultsTopographical modeling revealed the highest current densities in the anterior visual pathway, particularly retina and optic nerve. Stimulation parameters and finite element modeling estimates of rACS were found to be well below existing safety limits. No serious adverse events occurred. ConclusionOur findings are in line with existing safety guidelines for retinal and neural damage and establish the tolerability and feasibility of rACS. In comparison to tACS, retinofugal stimulation of the visual cortex provides an anatomically circumscribed model to systematically study the mechanisms of action of ACS.
URI: https://depositonce.tu-berlin.de/handle/11303/9903
http://dx.doi.org/10.14279/depositonce-8915
Issue Date: 7-Aug-2019
Date Available: 27-Aug-2019
DDC Class: 610 Medizin und Gesundheit
Subject(s): retinofugal alternating current stimulation
electrical stimulation
feasibility
tolerability
safety
adverse events
finite element modeling
License: https://creativecommons.org/licenses/by/4.0/
Journal Title: Frontiers in Neuroscience
Publisher: Frontiers Media S.A.
Publisher Place: Lausanne
Volume: 13
Article Number: 783
Publisher DOI: 10.3389/fnins.2019.00783
EISSN: 1662-453X
Appears in Collections:FG Neuronale Informationsverarbeitung » Publications

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