Please use this identifier to cite or link to this item: http://dx.doi.org/10.14279/depositonce-8936
Main Title: Zinc and Sepsis
Author(s): Alker, Wiebke
Haase, Hajo
Type: Article
Language Code: en
Abstract: Sepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and several studies imply a correlation between zinc and sepsis outcome. Therefore the alterations of zinc concentrations in different tissues might serve as one part of the host’s defense mechanism against pathogens during sepsis by diverse mechanisms. It has been suggested that zinc is involved in nutritional immunity, acts as a hepatoprotective agent, or a differentiation signal for innate immune cells, or supports the synthesis of acute phase proteins. Further knowledge about these events could help in the evaluation of how zinc could be optimally applied to improve treatment of septic patients. Moreover, the changes in zinc homeostasis are substantial and correlate with the severity of the disease, suggesting that zinc might also be useful as a diagnostic marker for evaluating the severity and predicting the outcome of sepsis.
URI: https://depositonce.tu-berlin.de/handle/11303/9926
http://dx.doi.org/10.14279/depositonce-8936
Issue Date: 27-Jul-2018
Date Available: 29-Aug-2019
DDC Class: 610 Medizin und Gesundheit
540 Chemie und zugeordnete Wissenschaften
Subject(s): zinc
sepsis
biomarker
supplementation
homeostasis
Sponsor/Funder: DFG, 316442145, FOR 2558: Interaktionen von essenziellen Spurenelementen in gesunden und erkrankten älteren Menschen (TraceAge)
DFG, 316442145, Immunmodulatorische Effekte von Spurenelementkombinationen auf das alternde Immunsystem
License: https://creativecommons.org/licenses/by/4.0/
Journal Title: Nutrients
Publisher: MDPI
Publisher Place: Basel
Volume: 10
Issue: 8
Article Number: 976
Publisher DOI: 10.3390/nu10080976
EISSN: 2072-6643
Appears in Collections:FG Lebensmittelchemie und Toxikologie » Publications

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