Please use this identifier to cite or link to this item:
Main Title: Exploiting Nonlinear Photoacoustic Signal Generation in Gold Nanospheres for Selective Detection in Serial 3D PA Tomography
Author(s): Schrof, Susanne
Pang, Genny
Buchmann, Jens
Laufer, Jan
Type: Article
Language Code: en
Abstract: The photoacoustic (PA) signal amplitude measured in gold nanosphere suspensions has been shown to increase nonlinearly with the incident excitation fluence. In this work, this effect is exploited to recover the spatial distribution of gold nanoparticles in tomographic 3D photoacoustic (PA) images against the background contrast provided by absorbers that exhibit a linear relationship between the PA signal amplitude and the fluence. Serial tomographic PA images of a tissue phantom containing gold nanospheres and a tissue-mimicking absorber were acquired. By assessing the linearity of the PA intensity voxel by voxel, the spatial distribution of the gold nanosphere suspension was recovered. The method is shown to enable the robust detection of gold nanoparticles.
Issue Date: 8-Dec-2018
Date Available: 30-Aug-2019
DDC Class: 541 Physikalische Chemie
Subject(s): photoacoustic tomography
gold nanospheres
plasmonic nanoparticles
image analysis
Sponsor/Funder: EC/FP7/281356/EU/Molecular photoacoustic imaging of stem-cell driven tissue regeneration/MOPIT
Journal Title: Journal of Imaging
Publisher: MDPI
Publisher Place: Basel
Volume: 4
Issue: 12
Article Number: 146
Publisher DOI: 10.3390/jimaging4120146
EISSN: 2313-433X
Appears in Collections:FG Nichtlineare Optik » Publications

Files in This Item:
File Description SizeFormat 
jimaging-04-00146-v2.pdf4.29 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons