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Hollow fibres integrated in a microfluidic cell culture system

Winkelmann, Claudia; Luo, Y.; Lode, A.; Gelinsky, M.; Marx, Uwe; Sonntag, Frank

For in vitro drug screening a modified perfusion micro-bioreactor system with integrated hollow fibres will be demonstrated. This biocompatible system consists of an integrated closed flow circuit that includes reservoirs and pneumatic micro pumps. Additional optical online-monitoring devices allow the observation during the cell cultivation. The embedded hollow fibre system which acts as cell carrier consists of a biodegradable biopolymer. One option to fabricate such 3D structures is the technology of Organ Printing which is realised by an adapted rapid prototyping system entitled 3D Scaffold Printer. With this device specimens consisting of tubes with a diameter smaller than 2 mm can be prepared. It should be possible to cultivate the hollow fibres inside and outside with different kinds of cells and therefore generate models of complex tissues.
Published in: Biomedical engineering = Biomedizinische Technik, 10.1515/bmt-2012-4213, De Gruyter
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  • This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.