The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis

dc.contributor.authorHuang, Shuhui
dc.contributor.authorLiu, Yushi
dc.contributor.authorLiu, Wan-Qiu
dc.contributor.authorNeubauer, Peter
dc.contributor.authorLi, Jian
dc.date.accessioned2021-05-19T07:06:48Z
dc.date.available2021-05-19T07:06:48Z
dc.date.issued2021-04-08
dc.date.updated2021-05-03T15:01:32Z
dc.description.abstractValinomycin is a nonribosomal peptide that was discovered from Streptomyces in 1955. Over the past more than six decades, it has received continuous attention due to its special chemical structure and broad biological activities. Although many research papers have been published on valinomycin, there has not yet been a comprehensive review that summarizes the diverse studies ranging from structural characterization, biogenesis, and bioactivity to the identification of biosynthetic gene clusters and heterologous biosynthesis. In this review, we aim to provide an overview of valinomycin to address this gap, covering from 1955 to 2020. First, we introduce the chemical structure of valinomycin together with its chemical properties. Then, we summarize the broad spectrum of bioactivities of valinomycin. Finally, we describe the valinomycin biosynthetic gene cluster and reconstituted biosynthesis of valinomycin. With that, we discuss possible opportunities for the future research and development of valinomycin.en
dc.identifier.eissn2076-2607
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/13126
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-11920
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc600 Technik, Technologiede
dc.subject.othervalinomycinen
dc.subject.othernonribiosomal peptideen
dc.subject.otherbioactivitiesen
dc.subject.otherbiosynthesisen
dc.subject.otherStreptomycesen
dc.subject.otherheterologous productionen
dc.subject.othercell-free biosynthesisen
dc.titleThe Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesisen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber780en
dcterms.bibliographicCitation.doi10.3390/microorganisms9040780en
dcterms.bibliographicCitation.issue4en
dcterms.bibliographicCitation.journaltitleMicroorganismsen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume9en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Bioverfahrenstechnikde
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Bioverfahrenstechnikde
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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