New Synthetic Routes for 1-Benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-Tetraazacyclododecane-1-acetic Acid Ethyl Ester, Important Starting Materials for Metal-coded DOTA-Based Affinity Tags
dc.contributor.author | Kohl, Stephan W. | |
dc.contributor.author | Kuse, Katharina | |
dc.contributor.author | Hummert, Markus | |
dc.contributor.author | Schumann, Herbert | |
dc.contributor.author | Mügge, Clemens | |
dc.contributor.author | Janek, Katharina | |
dc.contributor.author | Weißhoff, Hardy | |
dc.date.accessioned | 2018-10-10T07:34:26Z | |
dc.date.available | 2018-10-10T07:34:26Z | |
dc.date.issued | 2007 | |
dc.description.abstract | Two improved routes to synthesize 1-benzyl-1,4,7,10-tetraazacyclododecane (6) and 1,4,7,10- tetraazacyclododecane-1-acetic acid ethyl ester (11) are described as well as the synthesis of 1-{2-[4-(maleimido-N-propylacetamidobutyl)amino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane- 4,7,10-triacetic acid (17) and its Y, Ho, Tm, and Lu complexes. The 1H and 13C NMR spectra of the new compounds as well as the single crystal X-ray structure analyses of the intermediates 4-benzyl-1,7-bis(p-toluenesulfonyl)diethylenetriamine (3) and 1,4,7-tris(p-toluenesulfonyl)diethylenetriamine (7) are reported and discussed. The rare earth complexes of 17 have been characterized by 1H NMR spectroscopy and MALDI-TOF mass spectrometry. | en |
dc.description.sponsorship | DFG, SPP 1166, Lanthanoidspezifische Funktionalitäten in Molekül und Material | en |
dc.identifier.eissn | 1865-7117 | |
dc.identifier.issn | 0932-0776 | |
dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/8309 | |
dc.identifier.uri | http://dx.doi.org/10.14279/depositonce-7460 | |
dc.language.iso | en | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
dc.subject.other | Tetraazacyclododecane | en |
dc.subject.other | Macrocycle | en |
dc.subject.other | DOTA | en |
dc.subject.other | affinity tag | en |
dc.subject.other | rare earth complexes | en |
dc.title | New Synthetic Routes for 1-Benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-Tetraazacyclododecane-1-acetic Acid Ethyl Ester, Important Starting Materials for Metal-coded DOTA-Based Affinity Tags | en |
dc.type | Article | en |
dc.type.version | publishedVersion | en |
dcterms.bibliographicCitation.doi | 10.1515/znb-2007-0313 | |
dcterms.bibliographicCitation.issue | 3 | |
dcterms.bibliographicCitation.journaltitle | Zeitschrift für Naturforschung B | de |
dcterms.bibliographicCitation.originalpublishername | De Gruyter | en |
dcterms.bibliographicCitation.originalpublisherplace | Berlin | en |
dcterms.bibliographicCitation.pageend | 406 | |
dcterms.bibliographicCitation.pagestart | 397 | |
dcterms.bibliographicCitation.volume | 62 | |
tub.accessrights.dnb | free | |
tub.affiliation | Fak. 2 Mathematik und Naturwissenschaften::Inst. Chemie | de |
tub.affiliation.faculty | Fak. 2 Mathematik und Naturwissenschaften | de |
tub.affiliation.institute | Inst. Chemie | de |
tub.publisher.universityorinstitution | Technische Universität Berlin | de |
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