Anticipating alien cells with alternative genetic codes: away from the alanine world!

dc.contributor.authorKubyshkin, Vladimir
dc.contributor.authorBudisa, Nediljko
dc.date.accessioned2021-06-10T07:41:05Z
dc.date.available2021-06-10T07:41:05Z
dc.date.issued2019-07-03
dc.description.abstractCan we make life with a different genetic amino acid repertoire? Can we expect organisms which would keep newly given genetic code associations permanently? To address these questions, we would like to analyze the existent genetic code amino acid repertoire as formed from derivatives of alanine. Derivation from alanine leads to the α-helix based biological world, the Alanine World, whereas variations in the side-chains enable tertiary folding and subsequent chemical versatility of the proteome. Proline, glycine and pyrrolysine are the rudiments in the current genetic code, indicating that the original set could be different. Furthermore, from the perspective of peptide chemistry, it shall be possible to recruit these alternative scaffolds for the construction of synthetic or alternative life. This would allow for a completely new biological world, potentially as functional and versatile as the existing one. Pursuing these options offers a strategy for a complete re-design or even de-novo creation of living organisms based on entirely different chemical make-up, with completely new set of solutions for both near and distant future biotechnologies.en
dc.description.sponsorshipDFG, 390540038, EXC 2008: Unifying Systems in Catalysis "UniSysCat"en
dc.identifier.eissn1879-0429
dc.identifier.issn0958-1669
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/13231
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-12026
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.subject.otheralien cellsen
dc.subject.othergenetic codeen
dc.subject.otheralanineen
dc.titleAnticipating alien cells with alternative genetic codes: away from the alanine world!en
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1016/j.copbio.2019.05.006en
dcterms.bibliographicCitation.journaltitleCurrent Opinion in Biotechnologyen
dcterms.bibliographicCitation.originalpublishernameElsevieren
dcterms.bibliographicCitation.originalpublisherplaceAmsterdamen
dcterms.bibliographicCitation.pageend249en
dcterms.bibliographicCitation.pagestart242en
dcterms.bibliographicCitation.volume60en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften>Inst. Chemie>FG Biokatalysede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Biokatalysede
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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